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Current Oncology
Volume 19
Issue s1
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Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
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Article

Combined Performance of Physical Examination, Mammography, and Ultrasonography for Breast Cancer Screening among Chinese Women: A Follow-Up study

by
Y. Huang
1,
M. Kang
2,
H. Li
3,
J.Y. Li
1,*,
J.Y. Zhang
4,
L.H. Liu
2,
X.T. Liu
2,
Y. Zhao
1,
Q. Wang
1,
C.C. Li
1 and
H. Lee
1
1
Department of Epidemiology, West China School of Public Health, Sichuan University, Chengdu, Sichuan, China
2
Department of Radiology, Chengdu Women’s and Children’s Central Hospital, Chengdu, Sichuan, China
3
Department of Breast, Second People’s Hospital of Sichuan, Chengdu, Sichuan, China
4
Department of Biostatistics, West China School of Public Health, Sichuan University, Chengdu, Sichuan, China
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2012, 19(s1), 22-30; https://doi.org/10.3747/co.19.1137
Submission received: 2 April 2012 / Revised: 7 May 2012 / Accepted: 8 June 2012 / Published: 1 July 2012

Abstract

PE vte Objective: We aimed to determine which combination of physical examination (PE), mammography (MAM), and ultrasonography (US) would optimize breast cancer detection in China. Methods: We conducted a trial of screening with pe, mam, and us among Chinese women 25 years of age and older. All initial screenings using the three modalities were completed within 30 days of each other, and subjects were followed approximately 1 year later. The performances of the three screening methods used alone, in parallel, or in series were compared. Data were analyzed using exact confidence intervals (CIS) and the McNemar test. Results: Between March 2009 and July 2011, 3028 eligible women completed all study examinations. At a mean follow-up of 1.3 years, 33 breast cancers were identified in the study population. Mammography detected 28 cancers; US, 24 cancers; and PE, 22 cancers. During the follow-up period, 2 false-negative cases occurred clinically. The highest sensitivity for breast cancer screening (93.9%) was achieved by paralleling MAM with US, but came at the cost of a higher recall rate (12.15%). Using us alone at the first stage, followed by mam when indicated, offered high specificity (99.4%) and the lowest recall rate (1.82%), which were not reached at the expense of sensitivity (84.8%). Used in series, us and mam achieved a sensitivity similar to that for the same modalities used in parallel (McNemar p > 0.05). Conclusions: Taking limited health resources into consideration, the strategy of screening with US alone at the first stage, followed by mam when indicated, may optimize breast cancer detection in most regions of China.
Keywords: breast cancer; mass screening; mammography; ultrasonography; follow-up study; Chinese women breast cancer; mass screening; mammography; ultrasonography; follow-up study; Chinese women

Share and Cite

MDPI and ACS Style

Huang, Y.; Kang, M.; Li, H.; Li, J.Y.; Zhang, J.Y.; Liu, L.H.; Liu, X.T.; Zhao, Y.; Wang, Q.; Li, C.C.; et al. Combined Performance of Physical Examination, Mammography, and Ultrasonography for Breast Cancer Screening among Chinese Women: A Follow-Up study. Curr. Oncol. 2012, 19, 22-30. https://doi.org/10.3747/co.19.1137

AMA Style

Huang Y, Kang M, Li H, Li JY, Zhang JY, Liu LH, Liu XT, Zhao Y, Wang Q, Li CC, et al. Combined Performance of Physical Examination, Mammography, and Ultrasonography for Breast Cancer Screening among Chinese Women: A Follow-Up study. Current Oncology. 2012; 19(s1):22-30. https://doi.org/10.3747/co.19.1137

Chicago/Turabian Style

Huang, Y., M. Kang, H. Li, J.Y. Li, J.Y. Zhang, L.H. Liu, X.T. Liu, Y. Zhao, Q. Wang, C.C. Li, and et al. 2012. "Combined Performance of Physical Examination, Mammography, and Ultrasonography for Breast Cancer Screening among Chinese Women: A Follow-Up study" Current Oncology 19, no. s1: 22-30. https://doi.org/10.3747/co.19.1137

APA Style

Huang, Y., Kang, M., Li, H., Li, J. Y., Zhang, J. Y., Liu, L. H., Liu, X. T., Zhao, Y., Wang, Q., Li, C. C., & Lee, H. (2012). Combined Performance of Physical Examination, Mammography, and Ultrasonography for Breast Cancer Screening among Chinese Women: A Follow-Up study. Current Oncology, 19(s1), 22-30. https://doi.org/10.3747/co.19.1137

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