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Current Oncology
Volume 19
Issue s1
10.3747/co.19.1062
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Article

The Importance of a Satisfactory Biopsy for the Diagnosis of Lung Cancer in the Era of Personalized Treatment

by
L.M. Ofiara
1,*,
A. Navasakulpong
2,
N. Ezer
2 and
A.V. Gonzalez
2
1
Division of Respiratory Medicine, McGill University Health Centre, Montreal General Hospital, Montreal, QC, Canada
2
Division of Respiratory Medicine, McGill University Health Centre, Montreal Chest Hospital, Montreal, QC, Canada
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2012, 19(s1), 16-23; https://doi.org/10.3747/co.19.1062
Submission received: 7 March 2012 / Revised: 9 April 2012 / Accepted: 10 May 2012 / Published: 1 June 2012

Abstract

Advances in molecular biology are improving the understanding of lung cancer and changing the approach to treatment. A satisfactory biopsy that allows for histologic characterization and mutation analysis is becoming increasingly important. Most patients with lung cancer are diagnosed at an advanced stage, and diagnosis is often based on a small biopsy or cytology specimen. Here, we review the techniques available for making a diagnosis of lung cancer, including bronchoscopy, ultrasound-guided bronchoscopy, mediastinoscopy, transthoracic needle aspiration, thoracentesis, and medical thoracoscopy. We also discuss the indications, complications, and tissue yields of those techniques, especially as they pertain to testing for molecular markers.
Keywords: lung cancer; diagnosis; bronchoscopy; endobronchial ultrasonography; thoracoscopy; transthoracic needle aspiration; molecular markers; EGFR lung cancer; diagnosis; bronchoscopy; endobronchial ultrasonography; thoracoscopy; transthoracic needle aspiration; molecular markers; EGFR

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MDPI and ACS Style

Ofiara, L.M.; Navasakulpong, A.; Ezer, N.; Gonzalez, A.V. The Importance of a Satisfactory Biopsy for the Diagnosis of Lung Cancer in the Era of Personalized Treatment. Curr. Oncol. 2012, 19, 16-23. https://doi.org/10.3747/co.19.1062

AMA Style

Ofiara LM, Navasakulpong A, Ezer N, Gonzalez AV. The Importance of a Satisfactory Biopsy for the Diagnosis of Lung Cancer in the Era of Personalized Treatment. Current Oncology. 2012; 19(s1):16-23. https://doi.org/10.3747/co.19.1062

Chicago/Turabian Style

Ofiara, L.M., A. Navasakulpong, N. Ezer, and A.V. Gonzalez. 2012. "The Importance of a Satisfactory Biopsy for the Diagnosis of Lung Cancer in the Era of Personalized Treatment" Current Oncology 19, no. s1: 16-23. https://doi.org/10.3747/co.19.1062

APA Style

Ofiara, L. M., Navasakulpong, A., Ezer, N., & Gonzalez, A. V. (2012). The Importance of a Satisfactory Biopsy for the Diagnosis of Lung Cancer in the Era of Personalized Treatment. Current Oncology, 19(s1), 16-23. https://doi.org/10.3747/co.19.1062

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