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Current Oncology
Volume 18
Issue 4
10.3747/co.v18i4.815
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Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
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Review

A Single-Centre Chart Review Exploring the Adjusted Association between Breast Cancer Phenotype and Prognosis

by
C. Hamm
1,2,*,
M. El-Masri
1,2,
G. Poliquin
3,
V. Poliquin
3,
J. Mathews
1,
S. Kanjeekal
1,
Y. Alam
1,
S. Kulkarni
1 and
T. Elfiki
1
1
University of Western Ontario, London, ON, Canada
2
University of Windsor, Windsor, ON, Canada
3
University of Manitoba, Winnipeg, ON, Canada
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2011, 18(4), 191-196; https://doi.org/10.3747/co.v18i4.815
Submission received: 2 May 2011 / Revised: 3 June 2011 / Accepted: 4 July 2011 / Published: 1 August 2011

Abstract

Using a retrospective chart review, we investigated the differences in survival and prognostic factors between patients with triple-negative breast cancer (tnbc) and those with non-tnbc. The review included 1018 breast cancer patients who were diagnosed between 2000 and 2005 in Essex, Kent, and Lambton counties in Ontario, Canada. Our findings indicate that, although the unadjusted results suggested that patients with tnbc were more likely than patients with non-tnbc to die [hazard ratio (hr): 2.29; 95% confidence interval (ci): 1.33 to 2.93], an adjusted survival analysis revealed no significant difference in overall survival between the groups (hr: 1.22; 95% ci: 0.63 to 2.39). The significant predictors of survival in the adjusted analysis were age, stage of cancer, and size of cancer. Our findings support those of earlier reports, which suggest that presenting tumour size is the most important prognostic factor in tnbc. Investigations into unique screening methods to identify these tumours at an earlier stage and to prevent advanced-stage cancer in this patient subpopulation are necessary.
Keywords: Triple-negative breast cancer; survival; tumour size; cancer-related death; age Triple-negative breast cancer; survival; tumour size; cancer-related death; age

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MDPI and ACS Style

Hamm, C.; El-Masri, M.; Poliquin, G.; Poliquin, V.; Mathews, J.; Kanjeekal, S.; Alam, Y.; Kulkarni, S.; Elfiki, T. A Single-Centre Chart Review Exploring the Adjusted Association between Breast Cancer Phenotype and Prognosis. Curr. Oncol. 2011, 18, 191-196. https://doi.org/10.3747/co.v18i4.815

AMA Style

Hamm C, El-Masri M, Poliquin G, Poliquin V, Mathews J, Kanjeekal S, Alam Y, Kulkarni S, Elfiki T. A Single-Centre Chart Review Exploring the Adjusted Association between Breast Cancer Phenotype and Prognosis. Current Oncology. 2011; 18(4):191-196. https://doi.org/10.3747/co.v18i4.815

Chicago/Turabian Style

Hamm, C., M. El-Masri, G. Poliquin, V. Poliquin, J. Mathews, S. Kanjeekal, Y. Alam, S. Kulkarni, and T. Elfiki. 2011. "A Single-Centre Chart Review Exploring the Adjusted Association between Breast Cancer Phenotype and Prognosis" Current Oncology 18, no. 4: 191-196. https://doi.org/10.3747/co.v18i4.815

APA Style

Hamm, C., El-Masri, M., Poliquin, G., Poliquin, V., Mathews, J., Kanjeekal, S., Alam, Y., Kulkarni, S., & Elfiki, T. (2011). A Single-Centre Chart Review Exploring the Adjusted Association between Breast Cancer Phenotype and Prognosis. Current Oncology, 18(4), 191-196. https://doi.org/10.3747/co.v18i4.815

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