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Current Oncology
  • Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
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  • Open Access

1 August 2011

A Comprehensive Bone-Health Management Approach for Men with Prostate Cancer Receiving Androgen Deprivation Therapy

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1
Department of Physical Therapy, School of Medical Rehabilitation, University of Manitoba, Winnipeg, MB, Canada
2
Department of Internal Medicine and Department of Radiology, University of Manitoba, Winnipeg, MB, Canada
3
Department of Medical Oncology and Haematology, Cancer Care Manitoba, and Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada
4
Department of Pharmacy, Cancer Care Manitoba, Winnipeg, MB, Canada

Abstract

For advanced and metastatic prostate cancer, androgen deprivation therapy (adt) is the mainstay of treatment. Awareness of the potential bone-health complications consequent to adt use is increasing. Many studies have shown that prolonged adt leads to significant bone loss and increased fracture risk that negatively affect quality of life. Clinical practice guidelines for preserving bone health in men with prostate cancer on adt vary across Canada. This paper reviews recent studies on bone health in men with prostate cancer receiving adt and the current evidence regarding bone-health monitoring and management in reference to Canadian provincial guidelines. Based on this narrative review, we provide general bone-health management recommendations for men with prostate cancer receiving adt.

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