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Volume 4
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10.3390/nutraceuticals4030021
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Article

Antiglycation Effect of Jabuticaba (Plinia cauliflora) and Its Potential Role in Delaying Cataract Formation in Streptozotocin-Induced Diabetic Rats

by
Arif Yanuar Ridwan
*,
Yuki Shimozu
,
Nikesh Narang
,
Takashi Kometani
,
Yusuke Yamashita
and
Young-Il Kim
*
Pharma Foods International Co., Ltd., Kyoto 615-8245, Japan
*
Authors to whom correspondence should be addressed.
Nutraceuticals 2024, 4(3), 363-372; https://doi.org/10.3390/nutraceuticals4030021
Submission received: 16 April 2024 / Revised: 14 June 2024 / Accepted: 27 June 2024 / Published: 3 July 2024
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Abstract

Jabuticaba fruit (Plinia cauliflora) is widely consumed in various forms such as juice, jam, wine, and liquors; however, its potential therapeutic effects on diabetic complications remain inadequately explored. We aimed to investigate the potential antiglycation activity of Jabuticaba, identify the active compounds through bioassay-guided fractionation, and assess its effects on cataract formation in a Streptozotocin-induced diabetic type 1 rat model. Through bioassay-guided fractionation, we identified gallic acid (IC50: 24.7 µg/mL), protocatechuic acid (IC50: 1.22 µg/mL), and an ellagitannin, Repandinin B (IC50: 0.55 µg/mL), as active compounds contributing to antiglycation effects. In the animal study, the addition of Jabuticaba juice extract to the drinking water at a concentration of 0.5% (w/v) for 12 weeks demonstrated an amelioration in cataract progression. These results suggest that Jabuticaba has high antiglycation effects leading to the delaying of cataract formation in type 1 diabetes.
Keywords: Jabuticaba; glycation; ellagitannins; cataract Jabuticaba; glycation; ellagitannins; cataract

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MDPI and ACS Style

Ridwan, A.Y.; Shimozu, Y.; Narang, N.; Kometani, T.; Yamashita, Y.; Kim, Y.-I. Antiglycation Effect of Jabuticaba (Plinia cauliflora) and Its Potential Role in Delaying Cataract Formation in Streptozotocin-Induced Diabetic Rats. Nutraceuticals 2024, 4, 363-372. https://doi.org/10.3390/nutraceuticals4030021

AMA Style

Ridwan AY, Shimozu Y, Narang N, Kometani T, Yamashita Y, Kim Y-I. Antiglycation Effect of Jabuticaba (Plinia cauliflora) and Its Potential Role in Delaying Cataract Formation in Streptozotocin-Induced Diabetic Rats. Nutraceuticals. 2024; 4(3):363-372. https://doi.org/10.3390/nutraceuticals4030021

Chicago/Turabian Style

Ridwan, Arif Yanuar, Yuki Shimozu, Nikesh Narang, Takashi Kometani, Yusuke Yamashita, and Young-Il Kim. 2024. "Antiglycation Effect of Jabuticaba (Plinia cauliflora) and Its Potential Role in Delaying Cataract Formation in Streptozotocin-Induced Diabetic Rats" Nutraceuticals 4, no. 3: 363-372. https://doi.org/10.3390/nutraceuticals4030021

APA Style

Ridwan, A. Y., Shimozu, Y., Narang, N., Kometani, T., Yamashita, Y., & Kim, Y.-I. (2024). Antiglycation Effect of Jabuticaba (Plinia cauliflora) and Its Potential Role in Delaying Cataract Formation in Streptozotocin-Induced Diabetic Rats. Nutraceuticals, 4(3), 363-372. https://doi.org/10.3390/nutraceuticals4030021

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