1. Background
The World Health Organization (WHO) reported over 10.6 million new cases of tuberculosis (TB) worldwide in 2021, resulting in 1.4 million deaths. Ethiopia, one of the world’s high-burden countries, has an incidence rate of 126 per 100,000 people [
1]. In 2020, approximately 530 million adults worldwide were living with diabetes, with over a quarter living in low- and middle-income countries (LMICs); approximately 1.4 million adults in Ethiopia are living with diabetes [
2].
Studies have confirmed the epidemiological association between TB and DM [
3,
4,
5]. The coexistence of TB and type 2 diabetes mellitus (T2DM) represents a significant public health challenge in developing countries [
6,
7,
8]. This dual burden represents a significant public health concern, as it has the potential to exacerbate health outcomes, complicate treatment strategies [
9,
10], and increase the risk of treatment failure and mortality [
11,
12]. In 2021, the WHO reported that DM was a contributing factor in more than 2.72% of TB cases in Ethiopia [
1]. In addition, a systematic review and cross-sectional study conducted in Ethiopia revealed that 12.7% and 15.8% of cases had concurrent TB and DM, respectively [
8,
13]. The Ethiopian National Strategic Plan for Tuberculosis, set the objective of furnishing client-centered integrated TB and DM services, because the proportion of participants who receive TB and DM care in the country is low [
14].
Healthcare services are designed to provide coordinated care that addresses multiple health needs simultaneously, which is essential for the effective management of multi-morbidity [
15,
16]. Multi-morbidity is the co-occurrence of two or more chronic conditions in an individual [
17,
18]. In the context of Ethiopia, the health system faces significant challenges in providing healthcare services, mainly due to resource constraints, inadequate infrastructure and a lack of trained health workers [
19]. Despite these challenges, the integration of TB and DM care is imperative for improving patient outcomes and ensuring comprehensive management of both diseases [
20,
21].
Patients frequently encounter a multitude of obstacles when attempting to access healthcare services. These impediments include geographic isolation, financial constraints, and systematic inefficiencies within the healthcare system [
22,
23]. Moreover, deficiencies in the quality of care, such as inconsistencies in treatment protocols and inadequate follow-up, impede the effective management of patients with TB and DM [
16,
19,
22]. Understanding patients’ perspectives is crucial to TB-DM service delivery, as the literature has shown that experiences and attitudes have a significant impact on care seeking and adherence, whereas previous studies have emphasized the importance of incorporating patient perspectives in the development of ideal healthcare policies and practices [
24,
25,
26].
Cultural beliefs pertaining to TB and DM may influence patients’ health-seeking behaviors [
27]. In particular, the stigmatization of TB can act as a deterrent to individuals seeking necessary healthcare services. Moreover, research has demonstrated that the socio-economic, income level, educational, and employment characteristics of patients can influence their ability to access healthcare services, which in turn can affect their overall health outcomes [
28]. Despite the existing body of literature, there is a paucity of research investigating health system factors affecting the delivery of health services for patients with TB and T2DM multi-morbidity from the perspective of patients in Addis Ababa, Ethiopia.
This study was aimed at assessing factors affecting the provision of health services for patients with the multi-morbidity of TB-DM using the six elements of the SELFIE—
Sustainable int
Egrated chronic care mode
Ls for
Financ
Ing and performanc
E framework [
29].
2. Materials and Methods
2.1. Study Setting
The study was conducted in Addis Ababa, the capital of Ethiopia, with a population exceeding 3.8 million people. Administratively, the city is divided into ten sub-cities and 114 districts. The city has a total of 103 registered public health facilities, comprising 11 hospitals and 92 health centers [
30], which provide general services to the population.
2.2. Study Population
According to data from the Addis Ababa City Administration Health Bureau (Ethiopia Ministry of Health, 2015) [
31], there were 2563 adult patients with pulmonary TB and 405 who had been diagnosed with DM who actively sought health services at selected public health facilities in the city during the study period.
2.3. Study Design
A cross-sectional study was conducted with patients receiving care for TB and DM at health facilities in Addis Ababa using the six elements of the SELFIE (Sustainable intEgrated chronic care modeLs for FinancIng and performancE) framework.
2.4. Sampling Design and Sample Size Estimation
A three-stage cluster sampling design was used to select a sample.
In stage 1, 6 hospitals and 46 health centres were proportionally selected as a 50% sample from 11 hospitals and 92 health centres in Addis Ababa.
In stage 2, the baseline/source population for this study was 2563 patients with PTB and 405 with DM in the six hospitals and 46 health centres in the study community.
In stage 3, the sample size was calculated using a single population proportion formula at a 95% confidence interval and a 5% margin of error, and due to the absence of prior studies on the integration of TB-T2DM services, 50% was assumed to obtain maximum sample size.
where
Zα/2 = the value from standard normal distribution table for Z, which is 1.96,
P = the proportion of TB-T2DM service integration (50%),
1 − P = proportion of TB-T2DM service non-integration (50%), and
d = the margin of error
The total estimated sample size was 384 patients with TB-DM multimorbidity. Based on this sample size, we calculated the number of participants to be selected from each health facility.
2.5. Inclusion and Exclusion Criteria
The study included adult patients with pulmonary TB-T2DM but excluded those who declined to provide consent, were too critically ill at the time, exhibited clinical signs of SARS-CoV-2 infection, or had extra-pulmonary forms of TB-T2DM.
Operational Definition
TB-DM care was defined as the provision of coordinated services for both conditions within the same facility, including joint consultation, shared treatment planning and/or synchronized follow-up.
2.6. Data Collection Procedures
The survey questionnaire was adapted from the SELFIE framework which contained the following key factors: (a) service delivery—focusing on the delivery of care services to individuals with TB-DM multi-morbidity, (b) leadership & governance addressing the leadership and governance structures that support integrated care, (c) workforce involving HCWs involved in providing care and support to individuals with multi-morbidity, (d) financing of integrated care services, (e) technologies & medical products to support integrated care and (f) information and research to support the development and implementation of integrated care for TB-DM patients [
29].
The questionnaire was piloted on an internal sample of 20 TB-DM clients to identify questions that do not make sense to participants, or problems with the questionnaire that might lead to biased answers. Trained data collectors conducted face-to-face interviews with selected patients at sampled health facilities, during the participants’ scheduled visit for TB-DM care. The study was conducted between June and December 2023.
2.7. Data Management and Analysis
The collected data were checked, edited, coded and entered into the Statistical Package for Social Sciences (SPSS) version 32, for analysis. Descriptive analyses, including the calculations of means, medians, standard deviations, and frequency distribution tables, were conducted. Logistic regression analysis was conducted to identify the factors affecting the provision of health care for patients with TB and DM. The strength of the association was quantified via the adjusted odds ratio and a p value less than 0.05 was considered statistically significant.
2.8. Ethical Considerations
The College Research Ethics Committee (CREC) of the University of South Africa (Reference Number: 240815-052) and the Institutional Review Board of the Addis Ababa Health Bureau (Reference Number: A/A9869/227) granted ethical approval for this research. All the methods were carried out in accordance with the relevant guidelines and regulations. In addition, all the health facilities provided written permission.
3. Results
3.1. Demographic Characteristics of Participants
A total of 357 patients were enrolled in the study, with a response rate of 93%. The age of the participants ranged from 23–87 years, with a mean age of 49.87 ± 14.046 years. One-third of the participants were 60 years of age or older, while more than a quarter were between the ages of 40 and 49. Most of the participants were male (54.3%) and resided in urban areas (94.7%). The educational background of the participants was diverse, with 40.1% having obtained a diploma or higher education, 27.2% having completed secondary education, 20.4% having completed primary education, and 12.3% having no formal education (
Table 1).
3.2. Patient Perspectives on Service Delivery Factors Affecting Care for TB-DM
In this study, health services for TB and DM were delivered to only 13.4% (95% CI of 10.1% to 17.4%) of the patients across the 25% of the surveyed health facilities (in three hospitals and eleven health centers) (
Figure 1).
The results of the multivariate logistic regression analysis indicated that the provision of counseling on the proper use of medications (AOR = 2.6, CI: 1.1–6.6,
p < 0.001) and counseling about the risk of TB infection for diabetes patients (AOR = 10, CI: 3.7–27,
p < 0.001) influenced the provision of TB and DM services (
Table 2).
3.3. Leadership and Governance Factors Influencing the Provision of Care for Patients with TB-DM
The presence of supportive leadership and governance was found to have influence in receiving TB-DM healthcare services. Over three-quarters (77.1%) of TB-DM patients said they had supportive leadership in their health facilities, 62.5% of patients had received organised TB-DM care, 77.1% of respondents reported the existence of a policy for TB-DM care, while 58.3% of respondents said they had received continuous care for TB-DM (
Table 3).
3.4. Workforce Factors Affecting Care for Patients with TB-DM
Table 4 indicates that several health workforce factors positively influence health service provision for patients with TB-DM. Approximately 60.4% of patients said their care is improved if facilities have a multidisciplinary team, 58.3% if the facilities have a TB-DM service coordinator, 87.5% if health workers have adequate knowledge, and 50% if facilities involved informal caregivers in TB-DM.
3.5. Financial Factors Affecting Care for Patients with TB-DM
In Ethiopia, the costs of health services are covered by a Community-Based Health Insurance (CBHI) program which covers 80% of citizens. In 75% of facilities which have no mechanisms for reimbursing their healthcare costs and in 75% of health facilities where healthcare services are fair patients said they were more likely to receive decent healthcare for TB-DM (
Table 5).
3.6. Technologies & Medical Products Used for the Provision of Care for Patients with TB-DM
Only 12% of respondents said health facilities were using electronic medical record system, while 24.1% reported that their health facilities had access to technologies such as glucometers for monitoring blood sugar levels, acid-fast bacilli (AFB) tests to detect TB, GeneXpert to diagnose TB and drug resistance, chest X-rays for diagnosing TB, while 75.9% of patients did not have access to these technologies.
Around 65% of patients reported that their health facility did not have access to medical products for treating TB-DM, while 35.3% reported that their health facility had access to these products. These drugs are essential for the effective treatment and management of TB-DM.
Only 14.8% patients reported that their health facility had mechanisms to monitor the burden and care of TB-DM while a significant majority (85.2%) of patients reported that their health facilities did not have these mechanisms in place (
Table 6).
3.7. How Information and Research Are Used for the Provision of Care for Patients with TB-DM
Approximately 42.0% of TB-DM patients had access to individualised data for their condition, while 58.0% of patients did not have access to this data. More than a third of respondents, 35.6%, said that the individualised data they had helped to predict their level of risk to TB-DM.
Less than two-thirds, 61.3% of respondents, reported that health facilities had systems in place to protect the privacy of their data, while 38.7% did not have such systems in place. Over three-quarters of respondents, 78.4%, felt that access to their health information was important (
Table 7).
5. Conclusions
The study findings indicated that only a minority of patients in Addis Ababa, Ethiopia, had access to TB-DM services. From the patients’ perspective, the identified factors affecting the provision of services included the lack of provision of counseling on the proper use of medications, lack of counseling on the risk of TB infections for DM patients, the absence of organized TB-DM services, and the lack of integrated policies and the absence of a continuum of care.
To enhance care for patients with TB and DM in Addis Ababa, it is imperative that policymakers prioritize the strategies addressing TB and DM. The continuous monitoring of services and periodic assessments can facilitate the identification of care gaps, thereby guiding the implementation of improved interventions. Future studies should employ a mixed qualitative and quantitative methodology across multiple rural private healthcare sites, which would allow for a more in-depth exploration of the patient’s perspective.
Again, the study shows the many deficiencies of TBDM care in Addis Ababa. Lack of integration is one among many others.