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Protocol

Cardiopulmonary Rehabilitation in Long-COVID-19 Patients with Persistent Breathlessness and Fatigue: The COVID-Rehab Study

1
Research Center and Centre ÉPIC, Montreal Heart Institute, Montréal, QC H1T 1N6, Canada
2
Department of Medicine, Université de Montréal, Montréal, QC H3C 3J7, Canada
3
Department of Psychology, Université du Québec à Montréal, Montréal, QC H3C 3P8, Canada
4
Research Center, Institut Universitaire de Gériatrie de Montréal, Montréal, QC H3W 1W5, Canada
*
Author to whom correspondence should be addressed.
Academic Editors: Luenda E. Charles and Paul B. Tchounwou
Int. J. Environ. Res. Public Health 2022, 19(7), 4133; https://doi.org/10.3390/ijerph19074133
Received: 16 February 2022 / Revised: 16 March 2022 / Accepted: 24 March 2022 / Published: 31 March 2022
(1) Background: Cardiopulmonary and brain functions are frequently impaired after COVID-19 infection. Exercise rehabilitation could have a major impact on the healing process of patients affected by long COVID-19. (2) Methods: The COVID-Rehab study will investigate the effectiveness of an eight-week cardiopulmonary rehabilitation program on cardiorespiratory fitness (V˙O2max) in long-COVID-19 individuals. Secondary objectives will include functional capacity, quality of life, perceived stress, sleep quality (questionnaires), respiratory capacity (spirometry test), coagulation, inflammatory and oxidative-stress profile (blood draw), cognition (neuropsychological tests), neurovascular coupling and pulsatility (fNIRS). The COVID-Rehab project was a randomised clinical trial with two intervention arms (1:1 ratio) that will be blindly evaluated. It will recruit a total of 40 individuals: (1) rehabilitation: centre-based exercise-training program (eight weeks, three times per week); (2) control: individuals will have to maintain their daily habits. (3) Conclusions: Currently, there are no specific rehabilitation guidelines for long-COVID-19 patients, but preliminary studies show encouraging results. Clinicaltrials.gov (NCT05035628). View Full-Text
Keywords: COVID-19; long COVID; rehabilitation; cognition; exercise; physical activity; respiratory rehabilitation COVID-19; long COVID; rehabilitation; cognition; exercise; physical activity; respiratory rehabilitation
MDPI and ACS Style

Besnier, F.; Bérubé, B.; Malo, J.; Gagnon, C.; Grégoire, C.-A.; Juneau, M.; Simard, F.; L’Allier, P.; Nigam, A.; Iglésies-Grau, J.; Vincent, T.; Talamonti, D.; Dupuy, E.G.; Mohammadi, H.; Gayda, M.; Bherer, L. Cardiopulmonary Rehabilitation in Long-COVID-19 Patients with Persistent Breathlessness and Fatigue: The COVID-Rehab Study. Int. J. Environ. Res. Public Health 2022, 19, 4133. https://doi.org/10.3390/ijerph19074133

AMA Style

Besnier F, Bérubé B, Malo J, Gagnon C, Grégoire C-A, Juneau M, Simard F, L’Allier P, Nigam A, Iglésies-Grau J, Vincent T, Talamonti D, Dupuy EG, Mohammadi H, Gayda M, Bherer L. Cardiopulmonary Rehabilitation in Long-COVID-19 Patients with Persistent Breathlessness and Fatigue: The COVID-Rehab Study. International Journal of Environmental Research and Public Health. 2022; 19(7):4133. https://doi.org/10.3390/ijerph19074133

Chicago/Turabian Style

Besnier, Florent, Béatrice Bérubé, Jacques Malo, Christine Gagnon, Catherine-Alexandra Grégoire, Martin Juneau, François Simard, Philippe L’Allier, Anil Nigam, Josep Iglésies-Grau, Thomas Vincent, Deborah Talamonti, Emma G. Dupuy, Hânieh Mohammadi, Mathieu Gayda, and Louis Bherer. 2022. "Cardiopulmonary Rehabilitation in Long-COVID-19 Patients with Persistent Breathlessness and Fatigue: The COVID-Rehab Study" International Journal of Environmental Research and Public Health 19, no. 7: 4133. https://doi.org/10.3390/ijerph19074133

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