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Systematic Review

The Role of Exercise Training on Low-Grade Systemic Inflammation in Adults with Overweight and Obesity: A Systematic Review

1
Universidad de Alcalá, Facultad de Medicina y Ciencias de la Salud, Departamento de Ciencias Biomédicas, Área de Educación Física y Deportiva, 28871 Madrid, Spain
2
Division of Population Sciences, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA
*
Authors to whom correspondence should be addressed.
P.G.-E. and G.M. shared first-authorship.
Academic Editor: Paul B. Tchounwou
Int. J. Environ. Res. Public Health 2021, 18(24), 13258; https://doi.org/10.3390/ijerph182413258
Received: 14 November 2021 / Revised: 10 December 2021 / Accepted: 13 December 2021 / Published: 16 December 2021
Low-grade systemic inflammation leads to critical alterations of several tissues and organs that can promote the appearance of non-communicable diseases, a risk that is increased in adults with obesity. Exercise training may counteract low-grade systemic inflammation, but there is a lack of consensus on how cytokines are modulated by training in adults with obesity. This study aimed of examining the effects of exercise training on circulating pro- and anti-inflammatory cytokines in adults with overweight and obesity, and whether exercise-induced fat mass reduction could mediate that effect. The search was conducted on Medline (Pubmed), SPORTDiscus and Web of Science databases from January 1998 to August 2021, using keywords pertaining to inflammation, exercise, and obesity. A total of 27 studies were selected, in which the circulating concentration levels of cytokines were analyzed. Endurance training (ET) decreased circulating CRP, IL-6 and TNF-α levels. TNF-α was reduced after resistance and concurrent training (CT), while IL-10 increased after resistance training (RT). Changes in IL-10 and CRP coincided with fat mass reduction, while decreased TNF-α levels were concomitant with changes in IL-6 and IL-10. Exercise training may reduce systemic low-grade inflammation profile in adults with overweight and obesity. View Full-Text
Keywords: exercise immunology; low-grade inflammation; cytokines; fat mass; exercise exercise immunology; low-grade inflammation; cytokines; fat mass; exercise
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MDPI and ACS Style

Gonzalo-Encabo, P.; Maldonado, G.; Valadés, D.; Ferragut, C.; Pérez-López, A. The Role of Exercise Training on Low-Grade Systemic Inflammation in Adults with Overweight and Obesity: A Systematic Review. Int. J. Environ. Res. Public Health 2021, 18, 13258. https://doi.org/10.3390/ijerph182413258

AMA Style

Gonzalo-Encabo P, Maldonado G, Valadés D, Ferragut C, Pérez-López A. The Role of Exercise Training on Low-Grade Systemic Inflammation in Adults with Overweight and Obesity: A Systematic Review. International Journal of Environmental Research and Public Health. 2021; 18(24):13258. https://doi.org/10.3390/ijerph182413258

Chicago/Turabian Style

Gonzalo-Encabo, Paola, Gonzalo Maldonado, David Valadés, Carmen Ferragut, and Alberto Pérez-López. 2021. "The Role of Exercise Training on Low-Grade Systemic Inflammation in Adults with Overweight and Obesity: A Systematic Review" International Journal of Environmental Research and Public Health 18, no. 24: 13258. https://doi.org/10.3390/ijerph182413258

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