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Exposure to Heated Tobacco Products and Adverse Health Effects, a Systematic Review

Department of Hygiene and Epidemiology, Medical University of Lodz, 90-647 Lodz, Poland
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Academic Editors: David Ashley and Paul B. Tchounwou
Int. J. Environ. Res. Public Health 2021, 18(12), 6651; https://doi.org/10.3390/ijerph18126651
Received: 19 April 2021 / Revised: 16 June 2021 / Accepted: 17 June 2021 / Published: 21 June 2021
(This article belongs to the Special Issue New Perspective in Nicotine Use)
Heated tobacco products (HTP) are a form of nicotine delivery intended to be an alternative to traditional cigarettes. HTP tobacco products are sold to consumers as a less harmful alternative to traditional cigarettes, both for users and bystanders. The actual impact of HTP on the health of users and its overall impact on public health is still not fully known. A systematic search of the literature was carried out to identify relevant studies published in English from 2015 to February 2021. The following databases were used: PubMed, Scopus, Elsevier and ClinicalKey. 25 studies (independent and sponsored by the tobacco industry) were considered. The analysis of exposure biomarkers and cardiovascular and respiratory biomarkers showed differences between smokers and people using heated tobacco products. Improvements in clinically relevant risk markers, especially cholesterol, sICAM-1, 8-epi-PGF2α, 11-DTX-B2, HDL and FEV1, were observed compared to persistent cigarette smokers. On the other hand, exposure to IQOS has been reported to alter mitochondrial function, which may further exaggerate airway inflammation, airway remodeling and lung cancer. These products have the potential to increase oxidative stress and increase respiratory tract infections by increasing microbial adherence to the respiratory tract. Our review suggests that HTP products may be products with a reduced risk of chronic diseases, including respiratory and cardiovascular diseases and cancer compared to traditional smoking, although in the case of non-smokers so far, they may pose a risk of their occurrence. Research seems to be necessary to assess the frequency of HTP use and its potential negative health effects. View Full-Text
Keywords: heated tobacco products; heat-non-burn; IQOS; Glo; Ploom; adverse health effects heated tobacco products; heat-non-burn; IQOS; Glo; Ploom; adverse health effects
MDPI and ACS Style

Znyk, M.; Jurewicz, J.; Kaleta, D. Exposure to Heated Tobacco Products and Adverse Health Effects, a Systematic Review. Int. J. Environ. Res. Public Health 2021, 18, 6651. https://doi.org/10.3390/ijerph18126651

AMA Style

Znyk M, Jurewicz J, Kaleta D. Exposure to Heated Tobacco Products and Adverse Health Effects, a Systematic Review. International Journal of Environmental Research and Public Health. 2021; 18(12):6651. https://doi.org/10.3390/ijerph18126651

Chicago/Turabian Style

Znyk, Małgorzata, Joanna Jurewicz, and Dorota Kaleta. 2021. "Exposure to Heated Tobacco Products and Adverse Health Effects, a Systematic Review" International Journal of Environmental Research and Public Health 18, no. 12: 6651. https://doi.org/10.3390/ijerph18126651

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