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Effects of Aerobic and Resistance Exercise on Myokines in High Fat Diet-Induced Middle-Aged Obese Rats

Department of Physical Education, Keimyung University, Daegu 42601, Korea
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Int. J. Environ. Res. Public Health 2020, 17(8), 2685; https://doi.org/10.3390/ijerph17082685
Received: 18 March 2020 / Revised: 10 April 2020 / Accepted: 12 April 2020 / Published: 14 April 2020
(This article belongs to the Special Issue Exercise Medicine in Health and Disease)
The objective of this study was to analyze the effects of aerobic and resistance exercise on myokines expression in the skeletal muscle of middle-aged rats with high fat diet-induced obesity, to investigate the feasibility of using exercise training to reduce inflammation. Male 50-week-old Sprague Dawley rats were divided into normal diet, normal diet + exercise, high fat diet, and high fat diet + exercise groups. After six weeks on a high fat diet to induce obesity, a 12-week exercise program was implemented, which combined aerobic exercise (treadmill running) and resistance exercise (ladder climbing) three times a week for 75 min per session. We analyzed the protein levels of interleukins (IL) 6, 7, and 8, C-X-C motif chemokine receptor 2, and vascular endothelial growth factor in skeletal muscles by western blotting. Body weight decreased significantly during the 12-week exercise program in the exercise groups compared to the non-exercise groups (p < 0.05). The levels of all myokines analyzed were significantly lower in the skeletal muscle of the high fat diet group compared to the normal diet group (p < 0.05). After completing the 12-week exercise program, IL-7, IL-8, C-X-C motif chemokine receptor 2, and vascular endothelial growth factor expressions were significantly higher in the high fat diet + exercise group compared to the high fat diet group (p < 0.05). However, while IL-6 expression was significantly lower in the high fat diet and high fat diet + exercise groups compared to the normal diet group (p < 0.05), it was not significantly affected by exercise. In conclusion, high fat diet-induced obesity resulted in decreased myokines in the skeletal muscles, but combined exercise training of aerobic and resistance exercise increased myokines secretion in the skeletal muscle of obese rats, and is thought to help reduce inflammation. View Full-Text
Keywords: exercise; obesity; myokine; aging; skeletal muscle; rat exercise; obesity; myokine; aging; skeletal muscle; rat
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MDPI and ACS Style

Ahn, N.; Kim, K. Effects of Aerobic and Resistance Exercise on Myokines in High Fat Diet-Induced Middle-Aged Obese Rats. Int. J. Environ. Res. Public Health 2020, 17, 2685. https://doi.org/10.3390/ijerph17082685

AMA Style

Ahn N, Kim K. Effects of Aerobic and Resistance Exercise on Myokines in High Fat Diet-Induced Middle-Aged Obese Rats. International Journal of Environmental Research and Public Health. 2020; 17(8):2685. https://doi.org/10.3390/ijerph17082685

Chicago/Turabian Style

Ahn, Nayoung, and Kijin Kim. 2020. "Effects of Aerobic and Resistance Exercise on Myokines in High Fat Diet-Induced Middle-Aged Obese Rats" International Journal of Environmental Research and Public Health 17, no. 8: 2685. https://doi.org/10.3390/ijerph17082685

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