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Open AccessReview

Does Physical Activity Regulate Prostate Carcinogenesis and Prostate Cancer Outcomes? A Narrative Review

1
Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples “Federico II”, 80131 Naples, Italy
2
Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, Italy
3
Department of Precision Medicine, University of Campania Luigi Vanvitelli, 80131 Naples, Italy
4
Department of Mental Health and Public Medicine, University of Campania Luigi Vanvitelli, 80131 Naples, Italy
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(4), 1441; https://doi.org/10.3390/ijerph17041441
Received: 30 December 2019 / Revised: 20 February 2020 / Accepted: 20 February 2020 / Published: 24 February 2020
(This article belongs to the Special Issue Physical Activity and Elder Health)
Background: Prostate cancer (PCa) represents a common disease in men aged >65 years. The role of physical activity (PA) in patients at risk or diagnosed with PCa represents an evolving issue. We aimed to summarize available evidences about the impact of PA on the pathophysiology and clinical outcomes of PCa. Methods: We performed a narrative review. Evidences about the role of PA in elderly patients in terms of PCa biology, epidemiology, oncological and functional outcomes, as well as in terms of impact on the outcomes of androgen deprivation therapy (ADT) were summarized. Results: Potential pathophysiological pathways hypothesized to explain the benefits of PA in terms of prostate carcinogenesis include circulating levels of Insulin-like growth factor-1 (IGF-1), oxidative stress, systemic inflammation, sex hormones, and myokines. Clinically, emerging evidences support the hypothesis that PA is associated with decreased PCa risk, improved PCa-related survival, improved functional outcomes, and reduced ADT-related adverse events. View Full-Text
Keywords: prostate cancer; elderly; physical activity; cancer prevention; adjuvant treatment prostate cancer; elderly; physical activity; cancer prevention; adjuvant treatment
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MDPI and ACS Style

Capece, M.; Creta, M.; Calogero, A.; La Rocca, R.; Napolitano, L.; Barone, B.; Sica, A.; Fusco, F.; Santangelo, M.; Dodaro, C.; Sagnelli, C.; Carlomagno, N.; Crocetto, F.; Califano, G.; Mangiapia, F.; Longo, N. Does Physical Activity Regulate Prostate Carcinogenesis and Prostate Cancer Outcomes? A Narrative Review. Int. J. Environ. Res. Public Health 2020, 17, 1441.

AMA Style

Capece M, Creta M, Calogero A, La Rocca R, Napolitano L, Barone B, Sica A, Fusco F, Santangelo M, Dodaro C, Sagnelli C, Carlomagno N, Crocetto F, Califano G, Mangiapia F, Longo N. Does Physical Activity Regulate Prostate Carcinogenesis and Prostate Cancer Outcomes? A Narrative Review. International Journal of Environmental Research and Public Health. 2020; 17(4):1441.

Chicago/Turabian Style

Capece, Marco; Creta, Massimiliano; Calogero, Armando; La Rocca, Roberto; Napolitano, Luigi; Barone, Biagio; Sica, Antonello; Fusco, Ferdinando; Santangelo, Michele; Dodaro, Concetta; Sagnelli, Caterina; Carlomagno, Nicola; Crocetto, Felice; Califano, Gianluigi; Mangiapia, Francesco; Longo, Nicola. 2020. "Does Physical Activity Regulate Prostate Carcinogenesis and Prostate Cancer Outcomes? A Narrative Review" Int. J. Environ. Res. Public Health 17, no. 4: 1441.

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