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Open AccessArticle

Micronucleus Frequency in Exfoliated Buccal Cells of Children Living in an Industrialized Area of Apulia (Italy)

1
Department of Biological and Environmental Sciences and Technologies, University of Salento, 73100 Lecce, Italy
2
Institute for Research on Population and Social Policies, National Research Council (IRPPS-CNR), 72100 Brindisi, Italy
3
Institute of Clinical Physiology (CNR-IFC), 73100 Lecce, Italy
4
Regional Agency for Environmental Protection (ARPA Puglia), 70126 Bari, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Environ. Res. Public Health 2020, 17(4), 1208; https://doi.org/10.3390/ijerph17041208
Received: 17 December 2019 / Revised: 5 February 2020 / Accepted: 11 February 2020 / Published: 13 February 2020
(This article belongs to the Special Issue Children's Environmental Health)
Micronuclei (MN) are biomarkers of early biological effect often used for detecting DNA damage in human population exposed to genotoxic agents. The aim of this study was to evaluate the frequency of MN in exfoliated buccal cells of children living in an industrialized (impacted) area compared with that found in children living in a control area without significant anthropogenic impacts. A total of 462 6–8-year-old children (206 in the impacted area, 256 in the control area) attending primary school were enrolled. A questionnaire was administered to the parents of the recruited children to obtain information about personal data, lifestyles, and food habits of their children. Atmospheric particulate fractions were collected near the involved schools to assess the level of environmental exposure of the children. The presence of MN was highlighted in 68.4% of children living in the impacted area with a mean MN frequency of 0.66‰ ± 0.61‰. MN positivity and frequency were significantly lower in the control area (37.1% and 0.27‰ ± 0.43‰, respectively). The frequency of MN was positively associated with quasi-ultrafine particulate matter (PM0.5), traffic near the home, and consuming barbecued food; while adherence to the Mediterranean diet and practicing sport were negatively associated. View Full-Text
Keywords: micronuclei; buccal micronucleus cytome assay; children; environmental exposure; lifestyle; air pollution; quasi-ultrafine particles; PJS Study micronuclei; buccal micronucleus cytome assay; children; environmental exposure; lifestyle; air pollution; quasi-ultrafine particles; PJS Study
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Panico, A.; Grassi, T.; Bagordo, F.; Idolo, A.; Serio, F.; Tumolo, M.R.; De Giorgi, M.; Guido, M.; Tutino, M.; De Donno, A. Micronucleus Frequency in Exfoliated Buccal Cells of Children Living in an Industrialized Area of Apulia (Italy). Int. J. Environ. Res. Public Health 2020, 17, 1208.

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