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Effects of Lactoferrin on Prevention of Acute Gastrointestinal Symptoms in Winter: A Randomized, Double-Blinded, Placebo-Controlled Trial for Staff of Kindergartens and Nursery Schools in Japan

1
Department of Occupational Medicine, School of Medicine, Shinshu University, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan
2
Department of Preventive Medicine and Public Health, School of Medicine, Shinshu University, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan
3
Food Ingredients and Technology Institute, R&D Division, Morinaga Milk Industry Co., Ltd., Zama, Kanagawa 252-8583, Japan
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(24), 9582; https://doi.org/10.3390/ijerph17249582
Received: 11 November 2020 / Revised: 16 December 2020 / Accepted: 17 December 2020 / Published: 21 December 2020
(This article belongs to the Section Health Behavior, Chronic Disease and Health Promotion)
This study investigated the preventive effects of lactoferrin (LF) on subjective acute gastrointestinal symptoms during the winter in a randomized, double-blinded, placebo-controlled parallel-group comparative trial. The eligible subjects were healthy adults working at kindergartens and nursery schools. We randomized the subjects to the Placebo group (0 mg/day), the Low LF group (200 mg/day), and the High LF group (600 mg/day) for 12 weeks. The prevalence of acute gastrointestinal symptoms was significantly lower in the High LF (13/112 vs. 26/116; p = 0.030) and the Low LF (13/107 vs. 26/116; p = 0.040) groups than in the Placebo group. The adjusted odds ratio for the prevalence of acute gastrointestinal symptoms was 2.78 (95% CI: 1.19–6.47) in the Placebo group compared with the High LF group. LF is useful to prevent acute gastrointestinal symptoms among childcare workers, who mainly consist of women. View Full-Text
Keywords: lactoferrin; diarrhea; kindergarten; winter; subjective acute gastrointestinal symptoms lactoferrin; diarrhea; kindergarten; winter; subjective acute gastrointestinal symptoms
MDPI and ACS Style

Mizuki, M.; Tsukahara, T.; Oda, H.; Tanaka, M.; Yamauchi, K.; Abe, F.; Nomiyama, T. Effects of Lactoferrin on Prevention of Acute Gastrointestinal Symptoms in Winter: A Randomized, Double-Blinded, Placebo-Controlled Trial for Staff of Kindergartens and Nursery Schools in Japan. Int. J. Environ. Res. Public Health 2020, 17, 9582. https://doi.org/10.3390/ijerph17249582

AMA Style

Mizuki M, Tsukahara T, Oda H, Tanaka M, Yamauchi K, Abe F, Nomiyama T. Effects of Lactoferrin on Prevention of Acute Gastrointestinal Symptoms in Winter: A Randomized, Double-Blinded, Placebo-Controlled Trial for Staff of Kindergartens and Nursery Schools in Japan. International Journal of Environmental Research and Public Health. 2020; 17(24):9582. https://doi.org/10.3390/ijerph17249582

Chicago/Turabian Style

Mizuki, Masaru, Teruomi Tsukahara, Hirotsugu Oda, Miyuki Tanaka, Koji Yamauchi, Fumiaki Abe, and Tetsuo Nomiyama. 2020. "Effects of Lactoferrin on Prevention of Acute Gastrointestinal Symptoms in Winter: A Randomized, Double-Blinded, Placebo-Controlled Trial for Staff of Kindergartens and Nursery Schools in Japan" International Journal of Environmental Research and Public Health 17, no. 24: 9582. https://doi.org/10.3390/ijerph17249582

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