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Open AccessArticle

Randomized Clinical Trial of an Internet-Based Adolescent Depression Prevention Intervention in Primary Care: Internalizing Symptom Outcomes

1
The Robert S. and Grace W. Stone Primary Prevention Initiatives, Wellesley Centers for Women, Wellesley College, Wellesley, MA 02481, USA
2
Department of General Pediatrics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
3
Institute for Health Research and Policy, School of Public Health, University of Illinois at Chicago, Chicago, IL 60608, USA
4
University of Illinois Cancer Center, University of Illinois at Chicago, Chicago, IL 60612, USA
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(21), 7736; https://doi.org/10.3390/ijerph17217736
Received: 30 September 2020 / Revised: 16 October 2020 / Accepted: 20 October 2020 / Published: 22 October 2020
Approximately 20% of people will experience a depressive episode by adulthood, making adolescence an important developmental target for prevention. CATCH-IT (Competent Adulthood Transition with Cognitive-behavioral, Humanistic, and Interpersonal Training), an online depression prevention intervention, has demonstrated efficacy in preventing depressive episodes among adolescents reporting elevated symptoms. Our study examines the effects of CATCH-IT compared to online health education (HE) on internalizing symptoms in adolescents at risk for depression. Participants, ages 13–18, were recruited across eight US health systems and were randomly assigned to CATCH-IT or HE. Assessments were completed at baseline, 2, 6, 12, 18, and 24 months. There were no significant differences between groups in change in depressive symptoms (b = −0.31 for CATCH-IT, b = −0.27 for HE, p = 0.80) or anxiety (b = −0.13 for CATCH-IT, b = −0.11 for HE, p = 0.79). Improvement in depressive symptoms was statistically significant (p < 0.05) for both groups (p = 0.004 for CATCH-IT, p = 0.009 for HE); improvement in anxiety was significant for CATCH-IT (p = 0.04) but not HE (p = 0.07). Parental depression and positive relationships with primary care physicians (PRPC) moderated the anxiety findings, and adolescents’ externalizing symptoms and PRPC moderated the depression findings. This study demonstrates the long-term positive effects of both online programs on depressive symptoms and suggests that CATCH-IT demonstrates cross-over effects for anxiety as well. View Full-Text
Keywords: web-based interventions; internalizing symptoms; depressive symptoms; adolescents; prevention; primary care web-based interventions; internalizing symptoms; depressive symptoms; adolescents; prevention; primary care
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MDPI and ACS Style

Gladstone, T.; Buchholz, K.R.; Fitzgibbon, M.; Schiffer, L.; Lee, M.; Voorhees, B.W.V. Randomized Clinical Trial of an Internet-Based Adolescent Depression Prevention Intervention in Primary Care: Internalizing Symptom Outcomes. Int. J. Environ. Res. Public Health 2020, 17, 7736. https://doi.org/10.3390/ijerph17217736

AMA Style

Gladstone T, Buchholz KR, Fitzgibbon M, Schiffer L, Lee M, Voorhees BWV. Randomized Clinical Trial of an Internet-Based Adolescent Depression Prevention Intervention in Primary Care: Internalizing Symptom Outcomes. International Journal of Environmental Research and Public Health. 2020; 17(21):7736. https://doi.org/10.3390/ijerph17217736

Chicago/Turabian Style

Gladstone, Tracy; Buchholz, Katherine R.; Fitzgibbon, Marian; Schiffer, Linda; Lee, Miae; Voorhees, Benjamin W.V. 2020. "Randomized Clinical Trial of an Internet-Based Adolescent Depression Prevention Intervention in Primary Care: Internalizing Symptom Outcomes" Int. J. Environ. Res. Public Health 17, no. 21: 7736. https://doi.org/10.3390/ijerph17217736

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