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Article

Gestational Pesticide Exposure and Child Respiratory Health

1
Department of Family and Community Health, University of Maryland School of Nursing, Baltimore, MD 21201, USA
2
Office of Research and Scholarship, University of Maryland School of Nursing, Baltimore, MD 21201, USA
3
Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
4
Department of Health Sciences, Simon Fraser University, Burnaby, BC V5A 1S6, Canada
5
Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
6
Department of Epidemiology, Brown University, Providence, RI 02912, USA
7
Department of Pediatrics, Division of General Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(19), 7165; https://doi.org/10.3390/ijerph17197165
Received: 27 August 2020 / Revised: 21 September 2020 / Accepted: 24 September 2020 / Published: 30 September 2020
Background: Childhood wheeze may be related to pesticide exposure, and diet and genetics (Paroxonase; PON1) may modify the effects of exposure. Methods: We analyzed data from the HOME Study, a prospective pregnancy and birth cohort, to examine the association of gestational urinary organophosphate (OP) and pyrethroid (3PBA) metabolite concentrations with child wheeze, forced expiratory volume in one second (FEV1) at ages 4 and 5 years, and wheeze trajectory patterns through age 8 years. Results: Among 367 singletons, the frequency of wheeze ranged from 10.6% to 24.1% at each measurement age. OP and 3PBA metabolite concentrations were not associated with wheeze at 8 years or from birth to 8 years, but there were three significant interactions: (1) maternal daily fruit and vegetable consumption (less than daily consumption and increasing 3PBA was associated with wheeze at age 8 years, OR = 1.40), (2) maternal PON1-108 allele (CT/TT genotypes and high DE was associated with wheeze at age 8 years, OR = 2.13, 2.74) and (3) PON1192 alleles (QR/RR genotypes with higher diethylphosphate (DE) and dialkyl phosphate (DAP) were associated with wheeze at age 8 years, OR = 3.84). Pesticide metabolites were not consistently related to FEV1 or wheeze trajectory. Conclusions: Gestational OP and 3PBA metabolites were associated with child respiratory outcomes in participants with maternal dietary and genetic susceptibility. View Full-Text
Keywords: organophosphates; pyrethroids; gestational exposure; children; wheeze organophosphates; pyrethroids; gestational exposure; children; wheeze
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MDPI and ACS Style

Gilden, R.; Friedmann, E.; Holmes, K.; Yolton, K.; Xu, Y.; Lanphear, B.; Chen, A.; Braun, J.; Spanier, A. Gestational Pesticide Exposure and Child Respiratory Health. Int. J. Environ. Res. Public Health 2020, 17, 7165. https://doi.org/10.3390/ijerph17197165

AMA Style

Gilden R, Friedmann E, Holmes K, Yolton K, Xu Y, Lanphear B, Chen A, Braun J, Spanier A. Gestational Pesticide Exposure and Child Respiratory Health. International Journal of Environmental Research and Public Health. 2020; 17(19):7165. https://doi.org/10.3390/ijerph17197165

Chicago/Turabian Style

Gilden, Robyn, Erika Friedmann, Katie Holmes, Kimberly Yolton, Yingying Xu, Bruce Lanphear, Aimin Chen, Joseph Braun, and Adam Spanier. 2020. "Gestational Pesticide Exposure and Child Respiratory Health" International Journal of Environmental Research and Public Health 17, no. 19: 7165. https://doi.org/10.3390/ijerph17197165

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