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Open AccessArticle

Influence of Age on Partial Clinical Remission among Children with Newly Diagnosed Type 1 Diabetes

Department of Human Pathology in Adult and Developmental Age “Gaetano Barresi”, University of Messina, Via Consolare Valeria 1, 98124 Messina, Italy
Department of Economics, Unit of Statistical and Mathematical Sciences, University of Messina, 98124 Messina, Italy
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(13), 4801;
Received: 4 June 2020 / Revised: 17 June 2020 / Accepted: 30 June 2020 / Published: 3 July 2020
(This article belongs to the Special Issue Diabetes: Screening, Prevention, Diagnosis and Therapy)
Partial clinical remission (PCR) is a transitory period characterized by the residual endogenous insulin secretion following type 1 diabetes (T1D) diagnosis and introducing the insulin therapy. Scientific interest in PCR has been recently increasing, as this phase could be crucial to preserve functional beta cells after T1D onset, also taking advantage of new therapeutic opportunities. The aim of this study was to assess the frequency, duration and associated factors of PCR in children newly diagnosed with T1D. Our cohort study included 167 pediatric patients aged 13.8 ± 4.1 years. The association of clinical and laboratory factors with the occurrence and duration of PCR was evaluated via logistic regression and multivariable generalized linear model, respectively. PCR occurred in 63.5% of the examined patients. Patients who achieved the remission phase were significantly older, and they had lower daily insulin requirement compared with non-remitters. PCR was positively associated to body mass index (OR = 1.11; p = 0.032), pH value (OR 49.02; p = 0.003) and c-peptide levels (OR 12.8; p = 0.002). The average duration of PCR was 13.4 months, and older age at diagnosis was the only predictor factor. Two years after diagnosis remitter patients had lower HbA1c and daily insulin requirement. View Full-Text
Keywords: C-peptide; early diagnosis; length; GADA; honeymoon C-peptide; early diagnosis; length; GADA; honeymoon
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Passanisi, S.; Salzano, G.; Gasbarro, A.; Urzì Brancati, V.; Mondio, M.; Pajno, G.B.; Alibrandi, A.; Lombardo, F. Influence of Age on Partial Clinical Remission among Children with Newly Diagnosed Type 1 Diabetes. Int. J. Environ. Res. Public Health 2020, 17, 4801.

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