Next Article in Journal
Kinetics and Thermodynamics of Uranium (VI) Adsorption onto Humic Acid Derived from Leonardite
Previous Article in Journal
Key Messages in an Early Childhood Obesity Prevention Intervention: Are They Recalled and Do They Impact Children’s Behaviour?
Open AccessArticle

Relationship between the IL23R SNPs and Crohn’s Disease Susceptibility and Phenotype in the Polish and Bosnian Populations: A Case-Control Study

1
Department of Studies in Antropogenetics and Biogerontology, Pomeranian Medical University, Żołnierska 48, 71-210 Szczecin, Poland
2
Department of Gastroenterology, Pomeranian Medical University, Unii Lubelskiej 1, 71-252 Szczecin, Poland
3
Department of Gastroenterology and Hepatology, University Clinical Center Tuzla, Trnovac bb, 75000 Tuzla, Bosnia and Herzegovina
4
Department of Public Health, Pomeranian Medical University, Żołnierska 48, 71-210 Szczecin, Poland
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2019, 16(9), 1551; https://doi.org/10.3390/ijerph16091551
Received: 12 April 2019 / Revised: 26 April 2019 / Accepted: 28 April 2019 / Published: 2 May 2019
(This article belongs to the Section Health Behavior, Chronic Disease and Health Promotion)
It is suggested that IL-23/IL-17 axis and single nucleotide polymorphisms (SNPs) of IL23R may have crucial role in pathogenesis of Crohn’s disease (CD). Thus, we sought to assess the IL23R SNPs contribution to susceptibility and phenotype of CD. We recruited 117 CD subjects and 117 controls from Poland and 30 CD subjects and 30 controls from Bosnia and Herzegovina (B&H). Two common IL23R SNPs: rs1004819, rs7517847 were genotyped using TaqMan SNP assays. In the Polish population it was found that allele rs1004819: A increases the risk of CD, while allele rs7517847: A is protective against disease development. In Poles the co-carriage of two IL23R risk genotypes was associated with increased risk of CD. A significantly increased risk of CD early onset was observed in Poles carrying at least one rs7517847: G allele. It was also found that IL23R SNPs may be associated with structuring/penetrating CD behavior, as alleles rs1004819: A and rs7517847: G were significantly less frequent in patients without complications, from Poland and B&H, respectively. Allele rs1004819: A was also significantly more frequent in Poles with penetrating CD. These results confirm IL23R SNPs contribution to CD susceptibility in the Polish population and suggest their impact on early age of onset and more severe disease course. View Full-Text
Keywords: Crohn’s disease; IL23R; SNPs Crohn’s disease; IL23R; SNPs
MDPI and ACS Style

Borecki, K.; Zawada, I.; Salkić, N.N.; Karakiewicz, B.; Adler, G. Relationship between the IL23R SNPs and Crohn’s Disease Susceptibility and Phenotype in the Polish and Bosnian Populations: A Case-Control Study. Int. J. Environ. Res. Public Health 2019, 16, 1551.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop