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Open AccessArticle

Surgical Risk on Patients with Coagulopathies: Guidelines on Hemophiliac Patients for Oro-Maxillofacial Surgery

Multidisciplinary Department of Medical-Surgical and Odontostomatological Specialties, University of Campania “Luigi Vanvitelli”, 80100 Napoli, Italy
Department of Biomedical and Dental Sciences and Morphological and Functional Imaging, Messina University, 98100 Messina (ME), Italy
Department of Biomedical and Surgical and Biomedical Sciences Catania University, 95125 Catania (CT), Italy
Department of General Surgery and Medical-Surgery Specialties, University of Catania, 95125 Catania (CT), Italy
Department of Cardio-Thorax-Vascular and Transplant, A.O.U. Policlinico Catania, 95125 Catania (CT), Italy
Department of Maxillofacial Surgery, Loma Linda University, Loma Linda, CA 92350, USA
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2019, 16(8), 1386;
Received: 18 February 2019 / Revised: 29 March 2019 / Accepted: 10 April 2019 / Published: 17 April 2019
Background: Haemophilia is a disease of genetic origin, which causes a defect in blood coagulation. Under normal conditions, in the case of leakage from the blood vessels, the blood forms a clot that reduces or blocks the bleeding. This process involves the activation of several plasma proteins in a cascade-like species. Two of these proteins, produced in the liver, factor VIII and factor IX, are deficient or present a functional defect in people with haemophilia. Because of this deficit, the haemophiliacs easily suffer external and internal bleeding. Surgical treatment of these patients is to be observed, and often their treatment is delayed due to unclear guidelines and risks in treating these patients. The aim is to provide clear guidelines in the case of surgical treatment of these patients. Methods: In this study, we have considered all the guidelines that refer to the gold-maxillofacial surgery, focusing on the literature of the last 10 years. Results: Surely, this collection of guidelines will favor the choice of the clinician towards safer and predictable protocols. This study does not want to create a guideline but evaluates the literature of the last 10 years, and highlights the latest for the treatment of these patients., with the aim of informing the pathology and at the same time making the surgical maneuvers safer. Conclusions: Despite the research of literature has produced few results, it was nevertheless possible to draw up a guideline thanks to additional information extrapolated from textbooks and other scientific articles. According to the guidelines, it is possible to proceed to the treatment of these patients, if with appropriate therapy in a safe and risk-free manner. View Full-Text
Keywords: haemophilia; surgery; maxillo-facial; oral; coagulopathies; guidelines haemophilia; surgery; maxillo-facial; oral; coagulopathies; guidelines
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Laino, L.; Cicciù, M.; Fiorillo, L.; Crimi, S.; Bianchi, A.; Amoroso, G.; Monte, I.P.; Herford, A.S.; Cervino, G. Surgical Risk on Patients with Coagulopathies: Guidelines on Hemophiliac Patients for Oro-Maxillofacial Surgery. Int. J. Environ. Res. Public Health 2019, 16, 1386.

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