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Review

Linear Growth in Children and Adolescents with Type 1 Diabetes Mellitus

1
Pediatric Clinic, Department of Surgical and Biomedical Sciences, Università degli Studi di Perugia, 06123 Perugia, Italy
2
Pietro Barilla Children’s Hospital, Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2019, 16(19), 3677; https://doi.org/10.3390/ijerph16193677
Received: 9 July 2019 / Revised: 10 September 2019 / Accepted: 13 September 2019 / Published: 30 September 2019
(This article belongs to the Special Issue Child and Adolescent Health in a Life-Course Perspective)
Ensuring normal linear growth is one of the major therapeutic aims in the management of type one diabetes mellitus (T1DM) in children and adolescents. Many studies in the literature have shown that pediatric patients with T1DM frequently present some abnormalities in their growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis compared to their healthy peers. Data on the growth of T1DM children and adolescents are still discordant: Some studies have reported that T1DM populations, especially those whose diabetes began in early childhood, are taller than healthy pediatric populations at diagnosis, while other studies have not found any difference. Moreover, many reports have highlighted a growth impairment in T1DM patients of prepubertal and pubertal age, and this impairment seems to be influenced by suboptimal glycemic control and disease duration. However, the most recent data showed that children treated with modern intensive insulin therapies reach a normal final adult height. This narrative review aims to provide current knowledge regarding linear growth in children and adolescents with T1DM. Currently, the choice of the most appropriate therapeutic regimen to achieve a good insulin level and the best metabolic control for each patient, together with the regular measurement of growth parameters, remains the most important available tool for a pediatric diabetologist. Nevertheless, since new technologies are the therapy of choice in young children, especially those of pre-school age, it would be of great interest to evaluate their effects on the growth pattern of children with T1DM. View Full-Text
Keywords: diabetes mellitus; GH; IGF-1; linear growth; type 1 diabetes diabetes mellitus; GH; IGF-1; linear growth; type 1 diabetes
MDPI and ACS Style

Santi, E.; Tascini, G.; Toni, G.; Berioli, M.G.; Esposito, S. Linear Growth in Children and Adolescents with Type 1 Diabetes Mellitus. Int. J. Environ. Res. Public Health 2019, 16, 3677. https://doi.org/10.3390/ijerph16193677

AMA Style

Santi E, Tascini G, Toni G, Berioli MG, Esposito S. Linear Growth in Children and Adolescents with Type 1 Diabetes Mellitus. International Journal of Environmental Research and Public Health. 2019; 16(19):3677. https://doi.org/10.3390/ijerph16193677

Chicago/Turabian Style

Santi, Elisa, Giorgia Tascini, Giada Toni, Maria G. Berioli, and Susanna Esposito. 2019. "Linear Growth in Children and Adolescents with Type 1 Diabetes Mellitus" International Journal of Environmental Research and Public Health 16, no. 19: 3677. https://doi.org/10.3390/ijerph16193677

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