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Association between Resting Heart Rate and Colorectal Cancer: Results from a Case-Controlled Study

1
Department of Family Medicine, Yonsei University College of Medicine, Seoul 03722, Korea
2
Department of Medicine, Graduate School of Yonsei University College of Medicine, Seoul 03722, Korea
3
Department of Family Medicine, Yong-In Severance Hospital, Gyeonggi 17046, Korea
4
Biostatistics Collaboration Unit, Department of Research Affairs, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemoon-gu, Seoul 03722, Korea
5
Department of Sport Industry Studies, Yonsei University, Seoul 03722, Korea
6
Division of Colorectal Surgery, Department of Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this paper.
Int. J. Environ. Res. Public Health 2019, 16(16), 2883; https://doi.org/10.3390/ijerph16162883
Received: 19 July 2019 / Revised: 5 August 2019 / Accepted: 7 August 2019 / Published: 12 August 2019
(This article belongs to the Section Health Behavior, Chronic Disease and Health Promotion)
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Abstract

Previous studies evaluating associations between resting heart rate (RHR) and cancer-related mortality/prognosis have yielded conflicting results. We investigated whether elevations in RHR are associated with colorectal cancer (CRC). We conducted a case-controlled study involving 1241 CRC patients and 5909 cancer-free controls from the Korean National Health and Nutrition Examination Survey. After propensity score (PS) matching, 1207 CRC patients and 1207 matched controls were analyzed. Associations between RHR and CRC, colon, and rectal cancer were analyzed in appropriate patient subgroups using multiple and conditional logistic regression. Receiver operating characteristics analysis yielded the optimal RHR cut-point to predict CRC. RHR was significantly higher in CRC, colon, and rectal cancer patients than in controls (72.7 bpm in CRC, 72.8 bpm in colon cancer, 72.3 bpm in rectal cancer, and 68.7 bpm in controls; all p < 0.001). Analysis of data prior to PS matching yielded the following odds ratios (ORs) per RHR increment for CRC, colon, and rectal cancer: 1.043 (95% confidence intervals (CIs): 1.036–1.049), 1.045 (95% CI: 1.037–1.053), and 1.040 (95% CI: 1.030–1.051), respectively, in unadjusted models, and 1.043 (95% CI: 1.034–1.051), 1.046 (95% CI: 1.037–1.055), and 1.040 (95% CI: 1.027–1.052), respectively, in multivariable adjusted models. Patients with CRC, colon, and rectal cancer have a significantly higher RHR compared to cancer-free controls.
Keywords: colorectal cancer; colon cancer; rectal cancer; resting heart rate colorectal cancer; colon cancer; rectal cancer; resting heart rate
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Kwon, Y.-J.; Lee, H.S.; Cho, M.R.; Kim, S.N.; Jeon, J.Y.; Kim, N.K.; Lee, J.-W. Association between Resting Heart Rate and Colorectal Cancer: Results from a Case-Controlled Study. Int. J. Environ. Res. Public Health 2019, 16, 2883.

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