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Open AccessArticle

Activity of Antioxidant Enzymes and Their Association with Lipid Profile in Mexican People without Cardiovascular Disease: An Analysis of Interactions

1
CONACYT—Instituto Nacional de Cardiología ‘Ignacio Chávez’, Juan Badiano 1, Sección XVI, Tlalpan, Ciudad de México 14080, Mexico
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Laboratorio de Medicina Genómica del Hospital Regional Lic. Adolfo López Mateos, ISSSTE, Av. Universidad 1321, Florida, Álvaro Obregón, Ciudad de México 01030, Mexico
3
Departamento Biología, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México 04510, Mexico
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Departamento de Investigación Sociomédica, Instituto Nacional de Cardiología ‘Ignacio Chávez’ Juan Badiano 1, Sección XVI, Tlalpan, Ciudad de México 14080, Mexico
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Dirección de Investigación, Instituto Nacional de Cardiología ‘Ignacio Chávez’ Juan Badiano 1, Sección XVI, Tlalpan, Ciudad de México 14080, Mexico
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2018, 15(12), 2687; https://doi.org/10.3390/ijerph15122687
Received: 22 October 2018 / Revised: 17 November 2018 / Accepted: 24 November 2018 / Published: 28 November 2018
(This article belongs to the Section Health Behavior, Chronic Disease and Health Promotion)
Dyslipidemia and oxidative stress are both considered to be factors involved in cardiovascular disease; however, the relationship between them has been little explored. In this work, we studied the association between the lipid profile and the activity of antioxidant enzymes such as paraoxonase-1 (PON1), superoxide dismutase 1 (SOD1), ceruloplasmin, and catalase, as well as total antioxidant capacity (the ferric-reducing ability of plasma (FRAP)), in 626 volunteers without cardiovascular disease. Their lipid profile was evaluated, and they were classified as having or not having high triglycerides (↑TG), high low-density cholesterol (↑LDLC), and low high-density cholesterol (↓HDLC), resulting in eight groups: Without dyslipidemia, ↑TG, ↑LDLC, ↓HDLC, ↑TG↑LDLC, ↑TG↓HDLC, ↑LDLC↓HDLC, and ↑TG↑LDLC↓HDLC. When comparisons by group were made, no significant differences in the activity of antioxidant enzymes were obtained. However, the linear regression analysis considering the potential interactions between ↑TG, ↑LDLC, and ↓HDLC suggested a triple interaction between the three lipid profile alterations on the activity of PON1 and a double interaction between ↑TG and ↑LDLC on ferroxidase-ceruloplasmin activity. The analysis presented in this work showed an association between the lipid profile and antioxidant-enzyme activity and highlighted the importance of considering the interactions between the components of a phenomenon instead of studying them individually. Longitudinal studies are needed to elucidate the nature of these associations. View Full-Text
Keywords: dyslipidemia; cardiovascular risk; antioxidant activity; paraoxonase; superoxide dismutase; ceruloplasmin; catalase; ferric-reducing ability of plasma dyslipidemia; cardiovascular risk; antioxidant activity; paraoxonase; superoxide dismutase; ceruloplasmin; catalase; ferric-reducing ability of plasma
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Rivera-Mancía, S.; Jiménez-Osorio, A.S.; Medina-Campos, O.N.; Colín-Ramírez, E.; Vallejo, M.; Alcántara-Gaspar, A.; Cartas-Rosado, R.; Vargas-Barrón, J.; Pedraza-Chaverri, J. Activity of Antioxidant Enzymes and Their Association with Lipid Profile in Mexican People without Cardiovascular Disease: An Analysis of Interactions. Int. J. Environ. Res. Public Health 2018, 15, 2687.

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