Recent Advances on Inorganic Nanoparticle-Based Cancer Therapeutic Agents
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School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China
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Hunan Key Laboratory of Food Safety Science & Technology, Technology Center of Hunan Entry-Exit Inspection and Quarantine Bureau, Hunan Academy of Inspection and Quarantine, Changsha 410004, China
3
State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Huang-Tsung Chang
Int. J. Environ. Res. Public Health 2016, 13(12), 1182; https://doi.org/10.3390/ijerph13121182
Received: 25 September 2016 / Revised: 21 November 2016 / Accepted: 22 November 2016 / Published: 25 November 2016
(This article belongs to the Special Issue Nanomaterials-Based New Techniques, New Drugs, and Antibacterial Reagents)
Inorganic nanoparticles have been widely investigated as therapeutic agents for cancer treatments in biomedical fields due to their unique physical/chemical properties, versatile synthetic strategies, easy surface functionalization and excellent biocompatibility. This review focuses on the discussion of several types of inorganic nanoparticle-based cancer therapeutic agents, including gold nanoparticles, magnetic nanoparticles, upconversion nanoparticles and mesoporous silica nanoparticles. Several cancer therapy techniques are briefly introduced at the beginning. Emphasis is placed on how these inorganic nanoparticles can provide enhanced therapeutic efficacy in cancer treatment through site-specific accumulation, targeted drug delivery and stimulated drug release, with elaborations on several examples to highlight the respective strategies adopted. Finally, a brief summary and future challenges are included.
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Keywords:
cancer therapeutic agents; gold nanoparticles; magnetic nanoparticles; upconversion nanoparticles; mesoporous silica nanoparticles
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MDPI and ACS Style
Wang, F.; Li, C.; Cheng, J.; Yuan, Z. Recent Advances on Inorganic Nanoparticle-Based Cancer Therapeutic Agents. Int. J. Environ. Res. Public Health 2016, 13, 1182.
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