Next Article in Journal
A Longitudinal Study of Association between Heavy Metals and Itchy Eyes, Coughing in Chronic Cough Patients: Related with Non-Immunoglobulin E Mediated Mechanism
Previous Article in Journal
Housing Stakeholder Preferences for the “Soft” Features of Sustainable and Healthy Housing Design in the UK
Open AccessArticle

Association between UGT1A1 Polymorphism and Risk of Laryngeal Squamous Cell Carcinoma

1
Department of ear-nose-throat (ENT), the First Hospital of Shanxi Medical University, 85 Jiefangnan Road, Taiyuan, 030001 Shanxi, China
2
Department of biology, the Basic Medical School of Shanxi Medical University, 56 Xinjiannan Road, Taiyuan, 030001 Shanxi, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Int. J. Environ. Res. Public Health 2016, 13(1), 112; https://doi.org/10.3390/ijerph13010112
Received: 14 September 2015 / Accepted: 21 December 2015 / Published: 7 January 2016
Laryngeal cancer is one of the largest subgroups of head and neck cancers. In addition to smoking and alcohol consumption, genetic polymorphisms are also risk factors for the development of laryngeal cancer. However, the exact relation between genetic variants and pathogenesis of laryngeal cancer has remained elusive. The aim of this study was to examine UGT1A1*6 (rs4148323 A/G) polymorphisms in 103 patients with laryngeal cancer and 220 controls using the high resolution melting curve (HRM) technique and to explore the association between UGT1A1*6 (rs4148323 A/G) polymorphisms and laryngeal cancer. The results showed an association between the rs4148323 G allele and increased risk of laryngeal cancer. While there was no statistically significant difference between rs4148323 genotype frequencies and different histological grades or different clinical stages of laryngeal cancer, stratification analysis indicated smoking or alcohol consumption and rs4148323 G allele combined to increase the risk of laryngeal cancer. In conclusion, the rs4148323 G allele is associated with the high UGT1A1 enzyme activity, and might increase the risk of laryngeal cancer. Furthermore, smoking or alcohol consumption and the rs4148323 G allele act synergistically to increase the risk of laryngeal cancer. View Full-Text
Keywords: laryngeal squamous cell carcinoma; genetic polymorphism; UGT1A1; high resolution melting curve laryngeal squamous cell carcinoma; genetic polymorphism; UGT1A1; high resolution melting curve
Show Figures

Figure 1

MDPI and ACS Style

Huangfu, H.; Pan, H.; Wang, B.; Wen, S.; Han, R.; Li, L. Association between UGT1A1 Polymorphism and Risk of Laryngeal Squamous Cell Carcinoma. Int. J. Environ. Res. Public Health 2016, 13, 112.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop