Next Article in Journal
Oleic Acid Produced by a Marine Vibrio spp. Acts as an Anti-Vibrio parahaemolyticus Agent
Next Article in Special Issue
Pectenotoxin-2 from Marine Sponges: A Potential Anti-Cancer Agent—A Review
Previous Article in Journal
Important Determinants for Fucoidan Bioactivity: A Critical Review of Structure-Function Relations and Extraction Methods for Fucose-Containing Sulfated Polysaccharides from Brown Seaweeds
Previous Article in Special Issue
Anti-Biofilm Compounds Derived from Marine Sponges
Open AccessReview

Kinase Inhibitors from Marine Sponges

1
School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia
2
Centre for Medicinal Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia
*
Author to whom correspondence should be addressed.
Mar. Drugs 2011, 9(10), 2131-2154; https://doi.org/10.3390/md9102131
Received: 6 September 2011 / Revised: 1 October 2011 / Accepted: 14 October 2011 / Published: 24 October 2011
(This article belongs to the Special Issue Bioactive Compound from Marine Sponges)
Protein kinases play a critical role in cell regulation and their deregulation is a contributing factor in an increasing list of diseases including cancer. Marine sponges have yielded over 70 novel compounds to date that exhibit significant inhibitory activity towards a range of protein kinases. These compounds, which belong to diverse structural classes, are reviewed herein, and ordered based upon the kinase that they inhibit. Relevant synthetic studies on the marine natural product kinase inhibitors have also been included. View Full-Text
Keywords: marine sponges; marine natural products; protein kinase inhibitors; cell regulation; anticancer agents marine sponges; marine natural products; protein kinase inhibitors; cell regulation; anticancer agents
Show Figures

Graphical abstract

MDPI and ACS Style

Skropeta, D.; Pastro, N.; Zivanovic, A. Kinase Inhibitors from Marine Sponges. Mar. Drugs 2011, 9, 2131-2154.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop