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Mar. Drugs 2010, 8(7), 2080-2116;

Structures, Biological Activities and Phylogenetic Relationships of Terpenoids from Marine Ciliates of the Genus Euplotes

Bioorganic Chemistry Lab, Department of Physics, University of Trento, 38050 Povo, Trento, Italy
CNR, Istituto di Biofisica Trento, Via alla Cascata 56/C, 38050 Povo, Trento, Italy
Unit of Protistology, Department of Biology, University of Pisa, 56126 Pisa, Italy
Current address: School of Chemistry, University of Wollongong, Wollongong, 2522 NSW, Australia.
Author to whom correspondence should be addressed.
Received: 1 June 2010 / Revised: 6 July 2010 / Accepted: 6 July 2010 / Published: 8 July 2010
(This article belongs to the Special Issue Terpenoids of Marine Origin)
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In the last two decades, large scale axenic cell cultures of the marine species comprising the family Euplotidae have resulted in the isolation of several new classes of terpenoids with unprecedented carbon skeletons including the (i) euplotins, highly strained acetylated sesquiterpene hemiacetals; (ii) raikovenals, built on the bicyclo[3.2.0]heptane ring system; (iii) rarisetenolides and focardins containing an octahydroazulene moiety; and (iv) vannusals, with a unique C30 backbone. Their complex structures have been elucidated through a combination of nuclear magnetic resonance spectroscopy, mass spectrometry, molecular mechanics and quantum chemical calculations. Despite the limited number of biosynthetic experiments having been performed, the large diversity of ciliate terpenoids has facilitated the proposal of biosynthetic pathways whereby they are produced from classical linear precursors. Herein, the similarities and differences emerging from the comparison of the classical chemotaxonomy approach based on secondary metabolites, with species phylogenesis based on genetic descriptors (SSU-rDNA), will be discussed. Results on the interesting ecological and biological properties of ciliate terpenoids are also reported. View Full-Text
Keywords: marine ciliates; terpenoids; biosynthesis; bioactivity; phylogenetic relationships marine ciliates; terpenoids; biosynthesis; bioactivity; phylogenetic relationships

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Guella, G.; Skropeta, D.; Di Giuseppe, G.; Dini, F. Structures, Biological Activities and Phylogenetic Relationships of Terpenoids from Marine Ciliates of the Genus Euplotes. Mar. Drugs 2010, 8, 2080-2116.

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