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Marine Drugs
Volume 23
Issue 4
10.3390/md23040140
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Article

Comparative Analysis of Intestinal Microbiota Between Tetrodotoxin-Containing and Tetrodotoxin-Free Takifugu rubripes

by
Hanyuan Zhang
1,*,
Jilun Hou
2,
Youxiu Zhu
1,
Biyin Wu
1,
Jiangong Ren
2,
Zhaohui Sun
2 and
Xia Liu
2
1
Key Laboratory of Aquatic Genomics, Ministry of Agriculture and Rural Affairs, Beijing Key Laboratory of Fishery Biotechnology, Chinese Academy of Fishery Sciences, Beijing 100141, China
2
Beidaihe Central Experiment Station, Chinese Academy of Fishery Sciences, Qinhuangdao 066100, China
*
Author to whom correspondence should be addressed.
Mar. Drugs 2025, 23(4), 140; https://doi.org/10.3390/md23040140
Submission received: 7 February 2025 / Revised: 20 March 2025 / Accepted: 21 March 2025 / Published: 24 March 2025
(This article belongs to the Special Issue Commemorating the Launch of the Section "Marine Toxins")
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Abstract

Tetrodotoxin (TTX) is a potent marine neurotoxin found in pufferfish, causing severe poisoning or death if consumed improperly. Studies have indicated that intestinal symbiotic microbiota are associated with the production and accumulation of TTX in pufferfish. However, the specific symbiotic microorganisms involved in these processes and their respective functions remain unclear. This study explored differences in intestinal microbiota related to the TTX content between toxic and non-toxic tiger puffer Takifugu rubripes. We found that the dominant phyla exhibiting significant abundance differences between the two groups were Proteobacteria and Bacteroidota, with the core bacterial genera being Rikenella, Vibrio, Photobacterium, and Bacteroides. Moreover, the genera Marinimicrobium, Idomarina, Galbibacter, and Brumimicrobium were reported for the first time to be potentially associated with TTX bioaccumulation in T. rubripes. In addition, an integrated analysis with our previous study indicated that the “ABC transporters” pathway may play significant roles in the production and transport of TTX in both symbiotic microorganisms and T. rubripes. This study preliminarily investigated the intestinal symbiotic bacteria associated with the accumulation and metabolism of TTX in T. rubripes, as well as screening potential microbial biomarkers for assessing the safety of pufferfish.
Keywords: Takifugu rubripes; tetrodotoxin; 16S rRNA sequencing; intestinal microbiota; microbial function Takifugu rubripes; tetrodotoxin; 16S rRNA sequencing; intestinal microbiota; microbial function

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MDPI and ACS Style

Zhang, H.; Hou, J.; Zhu, Y.; Wu, B.; Ren, J.; Sun, Z.; Liu, X. Comparative Analysis of Intestinal Microbiota Between Tetrodotoxin-Containing and Tetrodotoxin-Free Takifugu rubripes. Mar. Drugs 2025, 23, 140. https://doi.org/10.3390/md23040140

AMA Style

Zhang H, Hou J, Zhu Y, Wu B, Ren J, Sun Z, Liu X. Comparative Analysis of Intestinal Microbiota Between Tetrodotoxin-Containing and Tetrodotoxin-Free Takifugu rubripes. Marine Drugs. 2025; 23(4):140. https://doi.org/10.3390/md23040140

Chicago/Turabian Style

Zhang, Hanyuan, Jilun Hou, Youxiu Zhu, Biyin Wu, Jiangong Ren, Zhaohui Sun, and Xia Liu. 2025. "Comparative Analysis of Intestinal Microbiota Between Tetrodotoxin-Containing and Tetrodotoxin-Free Takifugu rubripes" Marine Drugs 23, no. 4: 140. https://doi.org/10.3390/md23040140

APA Style

Zhang, H., Hou, J., Zhu, Y., Wu, B., Ren, J., Sun, Z., & Liu, X. (2025). Comparative Analysis of Intestinal Microbiota Between Tetrodotoxin-Containing and Tetrodotoxin-Free Takifugu rubripes. Marine Drugs, 23(4), 140. https://doi.org/10.3390/md23040140

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