Two New Chromone Derivatives from a Marine Algicolous Fungus Aspergillus versicolor GXIMD 02518 and Their Osteoclastogenesis Inhibitory Activity

Qi, Xin; Li, Zhen; Lin, Miaoping; Lu, Humu; Peng, Shuai; Qin, Huangxue; Liu, Yonghong; Gao, Chenghai; Luo, Xiaowei

doi:10.3390/md23110429

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Two New Chromone Derivatives from a Marine Algicolous Fungus Aspergillus versicolor GXIMD 02518 and Their Osteoclastogenesis Inhibitory Activity

by

Xin Qi

^1,†,

Zhen Li

^2,†,

Miaoping Lin

¹,

Humu Lu

¹,

Shuai Peng

¹,

Huangxue Qin

¹,

Yonghong Liu

¹

,

Chenghai Gao

^1,*

and

Xiaowei Luo

^1,*

¹

Guangxi Key Laboratory of Marine Drugs, University Engineering Research Center of High-Efficient Utilization of Marine Traditional Chinese Medicine Resources, Guangxi, Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China

²

School of Basic Medical Sciences, Hunan University of Medicine, Huaihua 418000, China

^*

Authors to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Mar. Drugs 2025, 23(11), 429; https://doi.org/10.3390/md23110429 (registering DOI)

Submission received: 10 October 2025 / Revised: 5 November 2025 / Accepted: 6 November 2025 / Published: 7 November 2025

(This article belongs to the Special Issue Advances in Secondary Metabolites from Mangrove Holobiont)

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Abstract

Two new chromone derivatives, cnidimols I and J (1 and 2), together with ten known aromatic derivatives (3–12), were isolated from the Beibu Gulf algicolous fungus Aspergillus versicolor GXIMD 02518. Their structures were determined by comprehensive physicochemical and spectroscopic data interpretation. The absolute configurations of 1 and 2 were accomplished by ECD calculations and X-ray diffraction analysis. Compound 1 was obtained as a pair of enantiomers, which were separated by chiral-phase HPLC analysis. Notably, 3,7-dihydroxy-1,9-dimethyldibenzofuran (6) displayed significant inhibition in LPS-induced NF-κB luciferase activity in RAW 264.7 macrophages, which further inhibited RANKL-induced osteoclast differentiation without cytotoxicity in bone marrow macrophage cells.

Keywords: marine algae; marine fungi; Aspergillus versicolor; chromones; polyketides; osteoclastogenesis

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MDPI and ACS Style

Qi, X.; Li, Z.; Lin, M.; Lu, H.; Peng, S.; Qin, H.; Liu, Y.; Gao, C.; Luo, X. Two New Chromone Derivatives from a Marine Algicolous Fungus Aspergillus versicolor GXIMD 02518 and Their Osteoclastogenesis Inhibitory Activity. Mar. Drugs 2025, 23, 429. https://doi.org/10.3390/md23110429

AMA Style

Qi X, Li Z, Lin M, Lu H, Peng S, Qin H, Liu Y, Gao C, Luo X. Two New Chromone Derivatives from a Marine Algicolous Fungus Aspergillus versicolor GXIMD 02518 and Their Osteoclastogenesis Inhibitory Activity. Marine Drugs. 2025; 23(11):429. https://doi.org/10.3390/md23110429

Chicago/Turabian Style

Qi, Xin, Zhen Li, Miaoping Lin, Humu Lu, Shuai Peng, Huangxue Qin, Yonghong Liu, Chenghai Gao, and Xiaowei Luo. 2025. "Two New Chromone Derivatives from a Marine Algicolous Fungus Aspergillus versicolor GXIMD 02518 and Their Osteoclastogenesis Inhibitory Activity" Marine Drugs 23, no. 11: 429. https://doi.org/10.3390/md23110429

APA Style

Qi, X., Li, Z., Lin, M., Lu, H., Peng, S., Qin, H., Liu, Y., Gao, C., & Luo, X. (2025). Two New Chromone Derivatives from a Marine Algicolous Fungus Aspergillus versicolor GXIMD 02518 and Their Osteoclastogenesis Inhibitory Activity. Marine Drugs, 23(11), 429. https://doi.org/10.3390/md23110429

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Two New Chromone Derivatives from a Marine Algicolous Fungus Aspergillus versicolor GXIMD 02518 and Their Osteoclastogenesis Inhibitory Activity

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