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Marine Drugs
Volume 20
Issue 3
10.3390/md20030201
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Article

Stimulating the Hematopoietic Effect of Simulated Digestive Product of Fucoidan from Sargassum fusiforme on Cyclophosphamide-Induced Hematopoietic Damage in Mice and Its Protective Mechanisms Based on Serum Lipidomics

by
Wei-Ping Ma
1,
Shi-Ning Yin
2,3,
Jia-Peng Chen
1,
Xi-Cheng Geng
1,
Ming-Fei Liu
1,
Hai-Hua Li
1,
Ming Liu
1,4,* and
Hong-Bing Liu
1,3,4,*
1
Key Laboratory of Marine Drugs, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
2
Qingdao Institute for Food and Drug Control, Qingdao 266000, China
3
NMPA Key Laboratory for Quality Research and Evaluation of Marine Traditional Chinese Medicine, Qingdao 266000, China
4
Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Science and Technology, Qingdao 266237, China
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2022, 20(3), 201; https://doi.org/10.3390/md20030201
Submission received: 11 February 2022 / Revised: 7 March 2022 / Accepted: 8 March 2022 / Published: 9 March 2022
(This article belongs to the Collection Marine Polysaccharides)
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Abstract

Hematopoietic damage is a serious side effect of cytotoxic drugs, and agents promoting hematopoiesis are quite important for decreasing the death rate in cancer patients. In our previous work, we prepared the simulated digestive product of fucoidan from Sargassum fusiforme, DSFF, and found that DSFF could activate macrophages. However, more investigations are needed to further evaluate whether DSFF could promote hematopoiesis in the chemotherapy process. In this study, the protective effect of DSFF (1.8–7.2 mg/kg, i.p.) on cyclophosphamide-induced hematopoietic damage in mice and the underlying mechanisms were investigated. Our results show that DSFF could restore the numbers of white blood cells, neutrophils, and platelets in the peripheral blood, and could also retard bone marrow cell decrease in mice with cyclophosphamide-induced hematopoietic damage. UPLC/Q-Extraction Orbitrap/MS/MS-based lipidomics results reveal 16 potential lipid biomarkers in a serum that responded to hematopoietic damage in mice. Among them, PC (20:1/14:0) and SM (18:0/22:0) were the key lipid molecules through which DSFF exerted protective actions. In a validation experiment, DSFF (6.25–100 μg/mL) could also promote K562 cell proliferation and differentiation in vitro. The current findings indicated that DSFF could affect the blood cells and bone marrow cells in vivo and thus showed good potential and application value in alleviating the hematopoietic damage caused by cyclophosphamide.
Keywords: Sargassum fusiforme fucoidan; hematopoietic damage; lipidomics Sargassum fusiforme fucoidan; hematopoietic damage; lipidomics
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MDPI and ACS Style

Ma, W.-P.; Yin, S.-N.; Chen, J.-P.; Geng, X.-C.; Liu, M.-F.; Li, H.-H.; Liu, M.; Liu, H.-B. Stimulating the Hematopoietic Effect of Simulated Digestive Product of Fucoidan from Sargassum fusiforme on Cyclophosphamide-Induced Hematopoietic Damage in Mice and Its Protective Mechanisms Based on Serum Lipidomics. Mar. Drugs 2022, 20, 201. https://doi.org/10.3390/md20030201

AMA Style

Ma W-P, Yin S-N, Chen J-P, Geng X-C, Liu M-F, Li H-H, Liu M, Liu H-B. Stimulating the Hematopoietic Effect of Simulated Digestive Product of Fucoidan from Sargassum fusiforme on Cyclophosphamide-Induced Hematopoietic Damage in Mice and Its Protective Mechanisms Based on Serum Lipidomics. Marine Drugs. 2022; 20(3):201. https://doi.org/10.3390/md20030201

Chicago/Turabian Style

Ma, Wei-Ping, Shi-Ning Yin, Jia-Peng Chen, Xi-Cheng Geng, Ming-Fei Liu, Hai-Hua Li, Ming Liu, and Hong-Bing Liu. 2022. "Stimulating the Hematopoietic Effect of Simulated Digestive Product of Fucoidan from Sargassum fusiforme on Cyclophosphamide-Induced Hematopoietic Damage in Mice and Its Protective Mechanisms Based on Serum Lipidomics" Marine Drugs 20, no. 3: 201. https://doi.org/10.3390/md20030201

APA Style

Ma, W.-P., Yin, S.-N., Chen, J.-P., Geng, X.-C., Liu, M.-F., Li, H.-H., Liu, M., & Liu, H.-B. (2022). Stimulating the Hematopoietic Effect of Simulated Digestive Product of Fucoidan from Sargassum fusiforme on Cyclophosphamide-Induced Hematopoietic Damage in Mice and Its Protective Mechanisms Based on Serum Lipidomics. Marine Drugs, 20(3), 201. https://doi.org/10.3390/md20030201

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