New Antiproliferative Compounds against Glioma Cells from the Marine-Sourced Fungus Penicillium sp. ZZ1750

Yong, Kuo; Kaleem, Sidra; Wu, Bin; Zhang, Zhizhen

doi:10.3390/md19090483

Open AccessArticle

New Antiproliferative Compounds against Glioma Cells from the Marine-Sourced Fungus Penicillium sp. ZZ1750

Ocean College, Zhejiang University, Zhoushan Campus, Zhoushan 316021, China

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Authors to whom correspondence should be addressed.

^†

Both the authors contribute equally to this paper.

Mar. Drugs 2021, 19(9), 483; https://doi.org/10.3390/md19090483

Submission received: 9 August 2021 / Revised: 25 August 2021 / Accepted: 25 August 2021 / Published: 26 August 2021

(This article belongs to the Special Issue Marine Fungal Metabolites: Structures, Activities and Biosynthesis)

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Abstract

Seven novel compounds, namely peniresorcinosides A–E (1–5), penidifarnesylin A (6), and penipyridinone A (7), together with the 11 known ones 8–17, were isolated from a culture of the marine-associated fungus Penicillium sp. ZZ1750 in rice medium. The structures of the new compounds were established based on their high-resolution electrospray ionization mass spectroscopy (HRESIMS) data, extensive nuclear magnetic resonance (NMR) spectroscopic analyses, chemical degradation, Mosher’s method, ¹³C-NMR calculations, electronic circular dichroism (ECD) calculations, and single crystal X-ray diffraction. Peniresorcinosides A (1) and B (2) are rare glycosylated alkylresorcinols and exhibited potent antiglioma activity, with IC₅₀ values of 4.0 and 5.6 µM for U87MG cells and 14.1 and 9.8 µM for U251 cells, respectively.

Keywords: marine fungus; Penicillium sp. ZZ1750; peniresorcinosides A–E; penidifarnesylin A; penipyridinone A; structure elucidation; antiglioma activity

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MDPI and ACS Style

Yong, K.; Kaleem, S.; Wu, B.; Zhang, Z. New Antiproliferative Compounds against Glioma Cells from the Marine-Sourced Fungus Penicillium sp. ZZ1750. Mar. Drugs 2021, 19, 483. https://doi.org/10.3390/md19090483

AMA Style

Yong K, Kaleem S, Wu B, Zhang Z. New Antiproliferative Compounds against Glioma Cells from the Marine-Sourced Fungus Penicillium sp. ZZ1750. Marine Drugs. 2021; 19(9):483. https://doi.org/10.3390/md19090483

Chicago/Turabian Style

Yong, Kuo, Sidra Kaleem, Bin Wu, and Zhizhen Zhang. 2021. "New Antiproliferative Compounds against Glioma Cells from the Marine-Sourced Fungus Penicillium sp. ZZ1750" Marine Drugs 19, no. 9: 483. https://doi.org/10.3390/md19090483

APA Style

Yong, K., Kaleem, S., Wu, B., & Zhang, Z. (2021). New Antiproliferative Compounds against Glioma Cells from the Marine-Sourced Fungus Penicillium sp. ZZ1750. Marine Drugs, 19(9), 483. https://doi.org/10.3390/md19090483

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New Antiproliferative Compounds against Glioma Cells from the Marine-Sourced Fungus Penicillium sp. ZZ1750

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