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Exploitation of Marine Molecules to Manage Alzheimer’s Disease

by 1,2, 3 and 3,4,5,*
1
MARE—Marine and Environmental Sciences Centre, Faculty of Sciences, University of Lisbon, Campo Grande, 1749-016 Lisbon, Portugal
2
Department of Plant Biology, Faculty of Science, University of Lisbon, Campo Grande, 1749-016 Lisbon, Portugal
3
Department of Pharmacology, Faculty of Pharmacy, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain
4
Department of Production and Characterization of Novel Foods, Institute of Food Science Research (CIAL), Campus of International Excellence UAM+CSIC, 28049 Madrid, Spain
5
Nutrition and Bromatology Group, CITACA, Faculty of Food Science and Technology, University of Vigo, Ourense Campus, 32004 Ourense, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Bill J. Baker
Mar. Drugs 2021, 19(7), 373; https://doi.org/10.3390/md19070373
Received: 2 June 2021 / Revised: 17 June 2021 / Accepted: 23 June 2021 / Published: 28 June 2021
Neurodegenerative diseases are sociosanitary challenges of today, as a result of increased average life expectancy, with Alzheimer’s disease being one of the most prevalent. This pathology is characterized by brain impairment linked to a neurodegenerative process culminating in cognitive decline and behavioral disorders. Though the etiology of this pathology is still unknown, it is usually associated with the appearance of senile plaques and neurofibrillary tangles. The most used prophylaxis relies on anticholinesterase drugs and NMDA receptor antagonists, whose main action is to relieve symptoms and not to treat or prevent the disease. Currently, the scientific community is gathering efforts to disclose new natural compounds effective against Alzheimer’s disease and other neurodegenerative pathologies. Marine natural products have been shown to be promising candidates, and some have been proven to exert a high neuroprotection effect, constituting a large reservoir of potential drugs and nutraceutical agents. The present article attempts to describe the processes of extraction and isolation of bioactive compounds derived from sponges, algae, marine bacteria, invertebrates, crustaceans, and tunicates as drug candidates against AD, with a focus on the success of pharmacological activity in the process of finding new and effective drug compounds. View Full-Text
Keywords: Alzheimer’s disease; marine drugs; sponges; algae; yields; natural products Alzheimer’s disease; marine drugs; sponges; algae; yields; natural products
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MDPI and ACS Style

Silva, M.; Seijas, P.; Otero, P. Exploitation of Marine Molecules to Manage Alzheimer’s Disease. Mar. Drugs 2021, 19, 373. https://doi.org/10.3390/md19070373

AMA Style

Silva M, Seijas P, Otero P. Exploitation of Marine Molecules to Manage Alzheimer’s Disease. Marine Drugs. 2021; 19(7):373. https://doi.org/10.3390/md19070373

Chicago/Turabian Style

Silva, Marisa, Paula Seijas, and Paz Otero. 2021. "Exploitation of Marine Molecules to Manage Alzheimer’s Disease" Marine Drugs 19, no. 7: 373. https://doi.org/10.3390/md19070373

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