Study on the Mechanism of the Blood-Glucose-Lowering Effect of Collagen Peptides from Sturgeon By-Products

Sasaoka, Yukiho; Takagi, Taichi; Michiba, Shunta; Yamamoto, Yohei; Kumagai, Yuya; Kishimura, Hideki

doi:10.3390/md19100584

Open AccessArticle

Study on the Mechanism of the Blood-Glucose-Lowering Effect of Collagen Peptides from Sturgeon By-Products

by

Yukiho Sasaoka

^1,*

,

Taichi Takagi

¹,

Shunta Michiba

¹,

Yohei Yamamoto

¹,

Yuya Kumagai

²

and

Hideki Kishimura

^2,*

¹

Marine Chemical Resource Development, Graduate School of Fisheries Sciences, Hokkaido University, Hakodate, Hokkaido 041-8611, Japan

²

Laboratory of Marine Chemical Resource Development, Faculty of Fisheries Sciences, Hokkaido University, Hakodate, Hokkaido 041-8611, Japan

^*

Authors to whom correspondence should be addressed.

Mar. Drugs 2021, 19(10), 584; https://doi.org/10.3390/md19100584

Submission received: 23 September 2021 / Revised: 13 October 2021 / Accepted: 15 October 2021 / Published: 19 October 2021

(This article belongs to the Special Issue Bioactive Peptides from Marine By-Products and Underused Marine Organisms)

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Abstract

In a previous study, we found that the collagen peptides prepared from the by-products of Bester sturgeon had an inhibitory effect on elevated blood glucose levels in a glucose tolerance test with ICR mice. In the present study, we examine the mechanism of the effect of sturgeon collagen peptides (SCPs) in detail. When glucose was orally administered to mice along with the SCPs, it was found that the glucose remained in the stomach for a longer time. In the above tests, the amount of glucose excreted in the feces of mice also increased. On the contrary, it was revealed that the SCPs have a dipeptidyl-peptidase-IV (DPP-IV) inhibitory ability in an in vitro test. In subsequent oral and intravenous glucose administration tests, glucagon-like peptide-1 (GLP-1) and insulin levels in the blood of mice were maintained at high levels. These results suggested the following three mechanisms: SCPs slow the rate of transportation of glucose from the stomach into the small intestine, resulting in delayed glucose absorption; SCPs suppress the absorption of glucose in the small intestine and excrete it from the body; SCPs inhibit DPP-IV in the blood and maintain a high GLP-1 level in blood, which in turn stimulates insulin secretion.

Keywords: sturgeon by-products; collagen peptides; blood glucose level; suppression of absorption; DPP-IV; GLP-1; insulin

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MDPI and ACS Style

Sasaoka, Y.; Takagi, T.; Michiba, S.; Yamamoto, Y.; Kumagai, Y.; Kishimura, H. Study on the Mechanism of the Blood-Glucose-Lowering Effect of Collagen Peptides from Sturgeon By-Products. Mar. Drugs 2021, 19, 584. https://doi.org/10.3390/md19100584

AMA Style

Sasaoka Y, Takagi T, Michiba S, Yamamoto Y, Kumagai Y, Kishimura H. Study on the Mechanism of the Blood-Glucose-Lowering Effect of Collagen Peptides from Sturgeon By-Products. Marine Drugs. 2021; 19(10):584. https://doi.org/10.3390/md19100584

Chicago/Turabian Style

Sasaoka, Yukiho, Taichi Takagi, Shunta Michiba, Yohei Yamamoto, Yuya Kumagai, and Hideki Kishimura. 2021. "Study on the Mechanism of the Blood-Glucose-Lowering Effect of Collagen Peptides from Sturgeon By-Products" Marine Drugs 19, no. 10: 584. https://doi.org/10.3390/md19100584

APA Style

Sasaoka, Y., Takagi, T., Michiba, S., Yamamoto, Y., Kumagai, Y., & Kishimura, H. (2021). Study on the Mechanism of the Blood-Glucose-Lowering Effect of Collagen Peptides from Sturgeon By-Products. Marine Drugs, 19(10), 584. https://doi.org/10.3390/md19100584

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Study on the Mechanism of the Blood-Glucose-Lowering Effect of Collagen Peptides from Sturgeon By-Products

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