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Marine Drugs
Volume 18
Issue 8
10.3390/md18080395
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Article

Preventive Effects of Three Polysaccharides on the Oxidative Stress Induced by Acrylamide in a Saccharomyces cerevisiae Model

by
Zhen Lin
,
Yu Zhang
,
Fangping Li
,
Xiaohui Tan
,
Ping Luo
and
Huazhong Liu
*
College of Chemistry & Environmental Science, Guangdong Ocean University, Zhanjiang 524088, China
*
Author to whom correspondence should be addressed.
Mar. Drugs 2020, 18(8), 395; https://doi.org/10.3390/md18080395
Submission received: 12 July 2020 / Revised: 21 July 2020 / Accepted: 27 July 2020 / Published: 28 July 2020
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Abstract

Saccharomyces cerevisiae was used as a model to explore the preventive effect of two marine polysaccharides separately derived from Sepia esculenta ink (SIP) and Laminaria japonica (FL) as well as one terrestrial polysaccharides from Eleocharis tuberosa peel (WCPP) on toxic injury induced by acrylamide (AA). The growth of yeast was evaluated by kinetics indexes including doubling time, lag phase and maximum proliferation density. Meanwhile, intracellular redox state was determined by contents of MDA and GSH, and SOD activity. The results showed that AA inhibited yeast growth and destroyed the antioxidant defense system. Supplement with polysaccharides, the oxidative damage of cells was alleviated. According to the growth recovery of yeast, FL and WCPP had similar degree of capacity against AA associated cytotoxicity, while SIP was 1.5~2 folds as strong as FL and WCPP. SIP and FL significantly reduced production of MDA by AA administration. Moreover, SIP, FL and WCPP increased SOD activity and repressed GSH depletion caused by AA.
Keywords: acrylamide; polysaccharides from Sepia esculenta ink; fucoidan from Laminaria japonica; polysaccharides from Eleocharis tuberosa peel; oxidative stress; Saccharomyces cerevisiae acrylamide; polysaccharides from Sepia esculenta ink; fucoidan from Laminaria japonica; polysaccharides from Eleocharis tuberosa peel; oxidative stress; Saccharomyces cerevisiae

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MDPI and ACS Style

Lin, Z.; Zhang, Y.; Li, F.; Tan, X.; Luo, P.; Liu, H. Preventive Effects of Three Polysaccharides on the Oxidative Stress Induced by Acrylamide in a Saccharomyces cerevisiae Model. Mar. Drugs 2020, 18, 395. https://doi.org/10.3390/md18080395

AMA Style

Lin Z, Zhang Y, Li F, Tan X, Luo P, Liu H. Preventive Effects of Three Polysaccharides on the Oxidative Stress Induced by Acrylamide in a Saccharomyces cerevisiae Model. Marine Drugs. 2020; 18(8):395. https://doi.org/10.3390/md18080395

Chicago/Turabian Style

Lin, Zhen, Yu Zhang, Fangping Li, Xiaohui Tan, Ping Luo, and Huazhong Liu. 2020. "Preventive Effects of Three Polysaccharides on the Oxidative Stress Induced by Acrylamide in a Saccharomyces cerevisiae Model" Marine Drugs 18, no. 8: 395. https://doi.org/10.3390/md18080395

APA Style

Lin, Z., Zhang, Y., Li, F., Tan, X., Luo, P., & Liu, H. (2020). Preventive Effects of Three Polysaccharides on the Oxidative Stress Induced by Acrylamide in a Saccharomyces cerevisiae Model. Marine Drugs, 18(8), 395. https://doi.org/10.3390/md18080395

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