Three New Sesquiterpenoids from the Algal-Derived Fungus Penicillium chermesinum EN-480
1
Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China
2
Laboratory of Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Wenhai Road 1, Qingdao 266237, China
3
College of Earth Science, University of Chinese Academy of Sciences, Yuquan Road 19A, Beijing 100049, China
4
Center for Ocean Mega-Science, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2020, 18(4), 194; https://doi.org/10.3390/md18040194
Received: 19 March 2020
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Revised: 30 March 2020
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Accepted: 1 April 2020
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Published: 7 April 2020
Secondary metabolites obtained from marine-derived fungi are rich sources of drug candidates. Three new sesquiterpenoids, chermesiterpenoids A–C (1–3), along with four known alkaloids (4–7), were isolated and identified from the marine red algal-derived fungus Penicillium chermesinum EN-480. The structures of these new sesquiterpenoids were elucidated using detailed analysis of the NMR data and their relative configurations were elucidated using nuclear overhauser effect spectroscopy (NOESY) spectra as well as gauge-independent atomic orbital (GIAO) NMR shift calculations and DP4+ probability analysis. Their absolute configurations were determined using electronic circular dichroism (ECD) calculations and modified Mosher’s method. Compounds 2 and 3 exhibited potent activities against human and aquatic pathogenic bacteria and plant pathogenic fungi.
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MDPI and ACS Style
Hu, X.-Y.; Li, X.-M.; Yang, S.-Q.; Liu, H.; Meng, L.-H.; Wang, B.-G. Three New Sesquiterpenoids from the Algal-Derived Fungus Penicillium chermesinum EN-480. Mar. Drugs 2020, 18, 194. https://doi.org/10.3390/md18040194
AMA Style
Hu X-Y, Li X-M, Yang S-Q, Liu H, Meng L-H, Wang B-G. Three New Sesquiterpenoids from the Algal-Derived Fungus Penicillium chermesinum EN-480. Marine Drugs. 2020; 18(4):194. https://doi.org/10.3390/md18040194
Chicago/Turabian StyleHu, Xue-Yi, Xiao-Ming Li, Sui-Qun Yang, Hui Liu, Ling-Hong Meng, and Bin-Gui Wang. 2020. "Three New Sesquiterpenoids from the Algal-Derived Fungus Penicillium chermesinum EN-480" Marine Drugs 18, no. 4: 194. https://doi.org/10.3390/md18040194
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