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Review

Chemical Diversity of Soft Coral Steroids and Their Pharmacological Activities

1
A.V. Zhirmunsky National Scientific Center of Marine Biology, 17 Palchevsky Str., 690041 Vladivostok, Russia
2
Institute of Biomedical Chemistry, bldg. 8, 10 Pogodinskaya Str., 119121 Moscow, Russia
3
Centre for Applied Research, Innovation and Entrepreneurship, Lethbridge College, 3000 College Drive South, Lethbridge, AB T1K 1L6, Canada
*
Author to whom correspondence should be addressed.
Mar. Drugs 2020, 18(12), 613; https://doi.org/10.3390/md18120613
Received: 20 October 2020 / Revised: 21 November 2020 / Accepted: 26 November 2020 / Published: 2 December 2020
(This article belongs to the Special Issue Marine-Derived Sterols)
The review is devoted to the chemical diversity of steroids produced by soft corals and their determined and potential activities. There are about 200 steroids that belong to different types of steroids such as secosteroids, spirosteroids, epoxy- and peroxy-steroids, steroid glycosides, halogenated steroids, polyoxygenated steroids and steroids containing sulfur or nitrogen heteroatoms. Of greatest interest is the pharmacological activity of these steroids. More than 40 steroids exhibit antitumor and related activity with a confidence level of over 90 percent. A group of 32 steroids shows anti-hypercholesterolemic activity with over 90 percent confidence. Ten steroids exhibit anti-inflammatory activity and 20 steroids can be classified as respiratory analeptic drugs. Several steroids exhibit rather rare and very specific activities. Steroids exhibit anti-osteoporotic properties and can be used to treat osteoporosis, as well as have strong anti-eczemic and anti-psoriatic properties and antispasmodic properties. Thus, this review is probably the first and exclusive to present the known as well as the potential pharmacological activities of 200 marine steroids. View Full-Text
Keywords: soft corals; steroids; chemical diversity; antitumor; anti-inflammatory; anti-eczemic; anti-psoriatic; biological activity prediction; PASS soft corals; steroids; chemical diversity; antitumor; anti-inflammatory; anti-eczemic; anti-psoriatic; biological activity prediction; PASS
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MDPI and ACS Style

Ermolenko, E.V.; Imbs, A.B.; Gloriozova, T.A.; Poroikov, V.V.; Sikorskaya, T.V.; Dembitsky, V.M. Chemical Diversity of Soft Coral Steroids and Their Pharmacological Activities. Mar. Drugs 2020, 18, 613. https://doi.org/10.3390/md18120613

AMA Style

Ermolenko EV, Imbs AB, Gloriozova TA, Poroikov VV, Sikorskaya TV, Dembitsky VM. Chemical Diversity of Soft Coral Steroids and Their Pharmacological Activities. Marine Drugs. 2020; 18(12):613. https://doi.org/10.3390/md18120613

Chicago/Turabian Style

Ermolenko, Ekaterina V., Andrey B. Imbs, Tatyana A. Gloriozova, Vladimir V. Poroikov, Tatyana V. Sikorskaya, and Valery M. Dembitsky. 2020. "Chemical Diversity of Soft Coral Steroids and Their Pharmacological Activities" Marine Drugs 18, no. 12: 613. https://doi.org/10.3390/md18120613

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