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Structure of the Polysaccharide Secreted by Vibrio alginolyticus CNCM I-5035 (Epidermist 4.0TM)

Centre de Recherches sur les Macromolécules Végétales (CERMAV), Université Grenoble Alpes, CNRS, 38000 Grenoble, France
Polymaris Biotechnology, 160 Rue Pierre Rivoalon, 29200 Brest, France
CODIF International, 35400 Roz-sur-Couesnon, France
Author to whom correspondence should be addressed.
Mar. Drugs 2020, 18(10), 509;
Received: 25 September 2020 / Accepted: 6 October 2020 / Published: 9 October 2020
(This article belongs to the Special Issue Marine Carbohydrate-Based Compounds with Medicinal Properties)
Vibrio alginolyticus (CNCM I-5035) secretes an exopolysaccharide used as ingredient in cosmetic industry under the trademark Epidermist 4.0TM. It is appreciated for its ability to improve the physical and chemical barrier functions of the skin by notably increasing the keratinocyte differentiation and epidermal renewal. Composition analyses and in depth characterization of the polysaccharides as well as oligosaccharides obtained by mild acid hydrolyses revealed that it was composed of a repetition unit of three residues: d-galactose (d-Gal), d-N-acetylglucosamine (GlcNAc) and l-N-acetylguluronic acid, of which 30% (M/M) was acetylated in position 3. The complete structure of the polysaccharide was resolved giving the repetition unit: [→3)-α-d-Gal-(1→4)-α-l-GulNAcA/α-l-3OAc-GulNAcA-(1→4)-β-d-GlcNAc-(1→]. View Full-Text
Keywords: exopolysaccharide; structure; NMR; Vibrio alginolyticus; Epidermist exopolysaccharide; structure; NMR; Vibrio alginolyticus; Epidermist
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Drouillard, S.; Chambon, R.; Jeacomine, I.; Buon, L.; Boisset, C.; Courtois, A.; Thollas, B.; Morvan, P.-Y.; Vallée, R.; Helbert, W. Structure of the Polysaccharide Secreted by Vibrio alginolyticus CNCM I-5035 (Epidermist 4.0TM). Mar. Drugs 2020, 18, 509.

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