Next Article in Journal
Metabolic Profiling of the Soft Coral Erythropodium caribaeorum (Alcyonacea: Anthothelidae) from the Colombian Caribbean Reveals Different Chemotypes
Next Article in Special Issue
Ectoine from Bacterial and Algal Origin Is a Compatible Solute in Microalgae
Previous Article in Journal
Microalgae with Immunomodulatory Activities
Previous Article in Special Issue
Monoacylglycerides from the Diatom Skeletonema marinoi Induce Selective Cell Death in Cancer Cells
Open AccessArticle

Protective Action of Ostreococcus Tauri and Phaeodactylum Tricornutum Extracts towards Benzo[a]Pyrene-Induced Cytotoxicity in Endothelial Cells

1
EA 2160 Mer Molécules Santé—MIMMA, IUML FR-3473 CNRS, Le Mans Université, F-53020 Laval, France
2
Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail)—UMR_S 1085, F-35000 Rennes, France
3
Microphyt, 713 Route de Mudaison, 34630 Baillargues, France
4
Univ Rennes, Biosit–UMS 3480, US_S 018, F-35000 Rennes, France
5
EA 2160 Mer Molécules Santé—MIMMA, IUML FR-3473 CNRS, Le Mans Université, F-72000 Le Mans, France
*
Authors to whom correspondence should be addressed.
Equal supervision.
Mar. Drugs 2020, 18(1), 3; https://doi.org/10.3390/md18010003
Received: 4 November 2019 / Revised: 13 December 2019 / Accepted: 14 December 2019 / Published: 18 December 2019
(This article belongs to the Special Issue Bioactive Compounds Derived from Marine Microalgae)
Marine microalgae are known to be a source of bioactive molecules of interest to human health, such as n-3 polyunsaturated fatty acids (n-3 PUFAs) and carotenoids. The fact that some of these natural compounds are known to exhibit anti-inflammatory, antioxidant, anti-proliferative, and apoptosis-inducing effects, demonstrates their potential use in preventing cancers and cardiovascular diseases (CVDs). Benzo[a]pyrene (B[a]P), a polycyclic aromatic hydrocarbon (PAH), is an ubiquitous environmental pollutant known to contribute to the development or aggravation of human diseases, such as cancer, CVDs, and immune dysfunction. Most of these deleterious effects are related to the activation of the polycyclic aromatic hydrocarbon receptor (AhR). In this context, two ethanolic microalgal extracts with concentrations of 0.1 to 5 µg/mL are tested, Ostreoccoccus tauri (OT) and Phaeodactylum tricornutum (PT), in order to evaluate and compare their potential effects towards B[a]P-induced toxicity in endothelial HMEC-1 cells. Our results indicate that the OT extract can influence the toxicity of B[a]P. Indeed, apoptosis and the production of extracellular vesicles were decreased, likely through the reduction of the expression of CYP1A1, a B[a]P bioactivation enzyme. Furthermore, the B[a]P-induced expression of the inflammatory cytokines IL-8 and IL1-β was reduced. The PT extract only inhibited the expression of the B[a]P-induced cytokine IL-8 expression. The OT extract therefore seems to be a good candidate for counteracting the B[a]P toxicity. View Full-Text
Keywords: Ostreococcus tauri; Phaeodactylum tricornutum; benzo[a]pyrene; endothelial cells; cell protection; cytokines; cell viability; mRNA expression; extracellular vesicles; aryl hydrocarbon receptor Ostreococcus tauri; Phaeodactylum tricornutum; benzo[a]pyrene; endothelial cells; cell protection; cytokines; cell viability; mRNA expression; extracellular vesicles; aryl hydrocarbon receptor
Show Figures

Figure 1

MDPI and ACS Style

Le Goff, M.; Delbrut, A.; Quinton, M.; Pradelles, R.; Bescher, M.; Burel, A.; Schoefs, B.; Sergent, O.; Lagadic-Gossmann, D.; Le Ferrec, E.; Ulmann, L. Protective Action of Ostreococcus Tauri and Phaeodactylum Tricornutum Extracts towards Benzo[a]Pyrene-Induced Cytotoxicity in Endothelial Cells. Mar. Drugs 2020, 18, 3.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop