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Bioactive Aliphatic Sulfates from Marine Invertebrates

Center for Research in Exact and Technological Sciences, University of Franca, Franca, São Paulo 14404-600, Brazil
Center for Natural and Human Sciences, Federal University of ABC, São Bernardo do Campo, São Paulo 09606-070, Brazil
School of Chemical Sciences, University of Auckland, Auckland 1142, New Zealand
Authors to whom correspondence should be addressed.
Mar. Drugs 2019, 17(9), 527;
Received: 4 August 2019 / Revised: 4 September 2019 / Accepted: 5 September 2019 / Published: 9 September 2019
The occurrence of sulfated steroids and phenolics in marine organisms is quite widespread, being typically reported from Echinoderms. In contrast, alkane and alkene aliphatic sulfates are considerably rarer with examples being reported from a diverse array of organisms including echinoderms, sponges and ascidians. While no ecological roles for these metabolites have been proposed, they do exhibit a diverse array of biological activities including thrombin inhibition; the ability to induce metamorphosis in larvae; antiproliferative, antibacterial and antifungal properties; and metalloproteinase inhibition. Of particular interest and an avenue for future development is the finding of antifouling properties with low or nontoxic effects to the environment. This review focuses on alkyl sulfates and related sulfamates, their structures and biological activities. Spectroscopic and spectrometric techniques that can be used to recognize the presence of sulfate groups are also discussed, data for which will enhance the ability of researchers to recognize this class of chemically- and biologically-interesting marine natural products. View Full-Text
Keywords: alkyl sulfate; aliphatic sulfate; alkane sulfate; alkene sulfate; marine invertebrates; bioactivity; NMR data alkyl sulfate; aliphatic sulfate; alkane sulfate; alkene sulfate; marine invertebrates; bioactivity; NMR data
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Kellner Filho, L.C.; Picão, B.W.; Silva, M.L.A.; Cunha, W.R.; Pauletti, P.M.; Dias, G.M.; Copp, B.R.; Bertanha, C.S.; Januario, A.H. Bioactive Aliphatic Sulfates from Marine Invertebrates. Mar. Drugs 2019, 17, 527.

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