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Open AccessArticle

New Peptides from The Marine-Derived Fungi Aspergillus allahabadii and Aspergillus ochraceopetaliformis

1
Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea
2
Department of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-921, Korea
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2019, 17(9), 488; https://doi.org/10.3390/md17090488
Received: 23 July 2019 / Revised: 19 August 2019 / Accepted: 19 August 2019 / Published: 21 August 2019
Four new peptides were isolated from the culture broths of the marine-derived fungi Aspergillus allahabadii and A. ochraceopetaliformis. Based on the results of chemical and spectroscopic analyses, two compounds (1 and 2) from A. allahabadii were determined to be cyclopentapeptides, while those from A. ochraceopetaliformis were a structurally-related cyclodepsihexapeptide (3) and its linear analog (4). In addition to the presence of a D-amino acid residue, the almost reversed sequence of peptides in 3 and 4, relative to those of the 1 and 2, is notable. These new compounds exhibited moderate inhibition against the enzyme sortase A as well as a weak inhibition against isocitrate lyase (2). View Full-Text
Keywords: peptides; marine-derived fungi; Aspergillus allahabadii; Aspergillus ochraceopetaliformis; isocitrate lyase; sortase A peptides; marine-derived fungi; Aspergillus allahabadii; Aspergillus ochraceopetaliformis; isocitrate lyase; sortase A
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MDPI and ACS Style

Hwang, J.-Y.; Lee, J.-H.; Park, S.C.; Lee, J.; Oh, D.-C.; Oh, K.-B.; Shin, J. New Peptides from The Marine-Derived Fungi Aspergillus allahabadii and Aspergillus ochraceopetaliformis. Mar. Drugs 2019, 17, 488.

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