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Open AccessArticle

Bathyptilones: Terpenoids from an Antarctic Sea Pen, Anthoptilum grandiflorum (Verrill, 1879)

1
Department of Chemistry, University of South Florida, Tampa, FL 33620, USA
2
Department of Cellular, Microbiology and Molecular Biology, University of South Florida, Tampa, FL 33620, USA
3
Western Australia Museum and the University of Western Australia, Perth, WA 6106, Australia
*
Author to whom correspondence should be addressed.
Mar. Drugs 2019, 17(9), 513; https://doi.org/10.3390/md17090513
Received: 31 July 2019 / Revised: 26 August 2019 / Accepted: 27 August 2019 / Published: 1 September 2019
An Antarctic coral belonging to the order Pennatulacea, collected during the 2013 austral autumn by trawl from 662 to 944 m depth, has yielded three new briarane diterpenes, bathyptilone A-C (13) along with a trinorditerpene, enbepeanone A (4), which bears a new carbon skeleton. Structure elucidation was facilitated by one- and two-dimensional NMR spectroscopy, mass spectrometry and confirmed by X-ray crystallography. The three compounds were screened in four cancer cell lines. Bathyptilone A displayed selective nanomolar cytotoxicity against the neurogenic mammalian cell line Ntera-2. View Full-Text
Keywords: briarane diterpene; cytotoxicity screening; deep sea; pennatulacea; marine natural products briarane diterpene; cytotoxicity screening; deep sea; pennatulacea; marine natural products
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Thomas, S.A.; Sanchez, A.; Kee, Y.; Wilson, N.G.; Baker, B.J. Bathyptilones: Terpenoids from an Antarctic Sea Pen, Anthoptilum grandiflorum (Verrill, 1879). Mar. Drugs 2019, 17, 513.

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