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Open AccessArticle

Production of New Antibacterial 4-Hydroxy-α-Pyrones by a Marine Fungus Aspergillus niger Cultivated in Solid Medium

1
Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315832, China
2
Department of Chemistry, College of Chemistry and Materials Science, Jinan University, Guangzhou 510632, China
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2019, 17(6), 344; https://doi.org/10.3390/md17060344
Received: 17 May 2019 / Revised: 3 June 2019 / Accepted: 5 June 2019 / Published: 10 June 2019
Four 4-hydroxy-α-pyrones including three new ones named nipyrones A–C (13) together with one known analogue germicidin C (4) were discovered from a marine sponge-derived fungus Aspergillus niger cultivated in a solid rice culture. Their structures and absolute configurations were elucidated through a combination of spectroscopic data and electronic circular dichroism (ECD) calculations as well as comparison with literature data. Compounds 14 were evaluated for their antibacterial activities against five pathogenic bacteria (Staphylococcus aureus, Escherichia coli, Bacillus subtilis, methicillin-resistant Staphylococcus aureus, and Mycobacterium tuberculosis). Compound 3 showed promising activity against S. aureus and B. subtilis, with minimum inhibitory concentration (MIC) values of 8 μg/mL and 16 μg/mL, respectively, and displayed weak antitubercular activities against M. tuberculosis, with MIC value of 64 μg/mL, while compounds 1 and 2 exhibited moderate antibacterial efficacy against four pathogenic bacteria with MIC values of 32–64 μg/mL. View Full-Text
Keywords: pyrone; sponge; marine fungi; ECD; antibacterial pyrone; sponge; marine fungi; ECD; antibacterial
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MDPI and ACS Style

Ding, L.; Ren, L.; Li, S.; Song, J.; Han, Z.; He, S.; Xu, S. Production of New Antibacterial 4-Hydroxy-α-Pyrones by a Marine Fungus Aspergillus niger Cultivated in Solid Medium. Mar. Drugs 2019, 17, 344.

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