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Cyclonerane Derivatives from the Algicolous Endophytic Fungus Trichoderma asperellum A-YMD-9-2

Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China
College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 100049, China
Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao 266071, China
Author to whom correspondence should be addressed.
Mar. Drugs 2019, 17(5), 252;
Received: 9 March 2019 / Revised: 23 April 2019 / Accepted: 26 April 2019 / Published: 28 April 2019
PDF [866 KB, uploaded 28 April 2019]


Seven previously unreported cyclonerane derivatives, namely, 3,7,11-trihydroxycycloneran-10-one, cycloneran-3,7,10,11-tetraol, cycloneran-3,7,11-triol, 11,12,15-trinorcycloneran-3,7,10-triol, 7,10S-epoxycycloneran-3,15-diol, 7,10R-epoxycycloneran-3,15-diol, and (10Z)-15-acetoxy-10-cycloneren-3,7-diol, were isolated in addition to the known (10Z)-cyclonerotriol, (10E)-cyclonerotriol, catenioblin C, and chokol E from the culture of Trichoderma asperellum A-YMD-9-2, an endophytic fungus obtained from the marine red alga Gracilaria verrucosa. The structures of previously unreported compounds were established by spectroscopic techniques, including 1D/2D NMR, MS, and IR. The isolation of these new cyclonerane derivatives greatly adds to the structural diversity of unusual cyclonerane sesquiterpenes, and several isolates exhibit potent inhibition against some marine phytoplankton species. View Full-Text
Keywords: Trichoderma asperellum; sesquiterpene; cyclonerane Trichoderma asperellum; sesquiterpene; cyclonerane

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Song, Y.-P.; Miao, F.-P.; Liu, X.-H.; Yin, X.-L.; Ji, N.-Y. Cyclonerane Derivatives from the Algicolous Endophytic Fungus Trichoderma asperellum A-YMD-9-2. Mar. Drugs 2019, 17, 252.

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