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Marine-Derived Natural Compounds for the Treatment of Parkinson’s Disease

by 1,2, 3 and 1,2,*
1
Ningbo Key Laboratory of Behavioral Neuroscience, Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo 315211, China
2
Laboratory of Marine Natural Products, School of Marine Sciences, Ningbo University, Ningbo 315211, China
3
Institute of New Drug Research, Guangdong Province Key Laboratory of Pharmacodynamic, Constituents of Traditional Chinese Medicine and New Drug Research, College of Pharmacy, Jinan University, Guangzhou 510632, China
*
Author to whom correspondence should be addressed.
Mar. Drugs 2019, 17(4), 221; https://doi.org/10.3390/md17040221
Received: 23 February 2019 / Revised: 23 March 2019 / Accepted: 5 April 2019 / Published: 11 April 2019
Parkinson’s disease (PD) is a neurodegenerative disorder caused by the loss of dopaminergic neurons, leading to the motor dysfunctions of patients. Although the etiology of PD is still unclear, the death of dopaminergic neurons during PD progress was revealed to be associated with the abnormal aggregation of α-synuclein, the elevation of oxidative stress, the dysfunction of mitochondrial functions, and the increase of neuroinflammation. However, current anti-PD therapies could only produce symptom-relieving effects, because they could not provide neuroprotective effects, stop or delay the degeneration of dopaminergic neurons. Marine-derived natural compounds, with their novel chemical structures and unique biological activities, may provide anti-PD neuroprotective effects. In this study, we have summarized anti-PD marine-derived natural products which have shown pharmacological activities by acting on various PD targets, such as α-synuclein, monoamine oxidase B, and reactive oxygen species. Moreover, marine-derived natural compounds currently evaluated in the clinical trials for the treatment of PD are also discussed. View Full-Text
Keywords: marine-derived natural compounds; Parkinson’s disease; α-synuclein; oxidative stress; neuroprotective; clinical trials marine-derived natural compounds; Parkinson’s disease; α-synuclein; oxidative stress; neuroprotective; clinical trials
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Huang, C.; Zhang, Z.; Cui, W. Marine-Derived Natural Compounds for the Treatment of Parkinson’s Disease. Mar. Drugs 2019, 17, 221.

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