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Open AccessArticle

Fucoidan Suppresses Mitochondrial Dysfunction and Cell Death against 1-Methyl-4-Phenylpyridinum-Induced Neuronal Cytotoxicity via Regulation of PGC-1α Expression

by Yong-Seok Han 1, Jun Hee Lee 1,2 and Sang Hun Lee 1,2,*
1
Medical Science Research Institute, Soonchunhyang University Seoul Hospital, Seoul 04401, Korea
2
Departments of Biochemistry, Soonchunhyang University College of Medicine, Cheonan 31151, Korea
*
Author to whom correspondence should be addressed.
Mar. Drugs 2019, 17(9), 518; https://doi.org/10.3390/md17090518
Received: 26 June 2019 / Revised: 7 August 2019 / Accepted: 29 August 2019 / Published: 2 September 2019
Mitochondria are considered to be the powerhouses of cells. They are the most commonly damaged organelles within dopaminergic neurons in patients with Parkinson’s disease (PD). Despite the importance of protecting neuronal mitochondria in PD patients, the detailed mechanisms underlying mitochondrial dysfunction during pathogenesis and pathophysiological progression of PD have not yet been elucidated. We investigated the protective action of fucoidan against the detrimental action of 1-methyl-4-phenyl-pyridinium (MPP+), a neurotoxin used to model PD, in the mitochondria of SH-SY5Y neural cells. Fucoidan increased the expression of peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) and protected the cells from MPP+-induced apoptosis by upregulating the 5′ adenosine monophosphate-activated protein kinase (AMPK)-PGC-1α axis. These effects were blocked by the silencing of the PGC-1α axis. These results indicated that fucoidan protects SH-SY5Y cells from mitochondrial dysfunction and cell death caused by MPP+ treatment, via the AMPK-PGC-1α axis. These findings also suggest that fucoidan could potentially be used as a therapeutic agent for PD. View Full-Text
Keywords: fucoidan; PGC-1α; Parkinson’s disease; mitochondrial dysfunction fucoidan; PGC-1α; Parkinson’s disease; mitochondrial dysfunction
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Han, Y.-S.; Lee, J.H.; Lee, S.H. Fucoidan Suppresses Mitochondrial Dysfunction and Cell Death against 1-Methyl-4-Phenylpyridinum-Induced Neuronal Cytotoxicity via Regulation of PGC-1α Expression. Mar. Drugs 2019, 17, 518.

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