Next Article in Journal
Preparation and Evaluation of Release Formulation of γ-Oryzanol/Algae Oil Self-Emulsified with Alginate Beads
Next Article in Special Issue
Intravenous Lipid Emulsions to Deliver Bioactive Omega-3 Fatty Acids for Improved Patient Outcomes
Previous Article in Journal
Antitumor Anthraquinones from an Easter Island Sea Anemone: Animal or Bacterial Origin?
Previous Article in Special Issue
Protective Effects of Fucoxanthin on Ultraviolet B-Induced Corneal Denervation and Inflammatory Pain in a Rat Model
Article Menu
Issue 3 (March) cover image

Export Article

Open AccessArticle

Correlation between Fatty Acid Profile and Anti-Inflammatory Activity in Common Australian Seafood by-Products

1
Marine Ecology Research Centre, Southern Cross University, Lismore 2480, Australia
2
Division of Research & Innovation, University of Southern Queensland, Toowoomba 4350, Australia
3
Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Australia
4
Southern Cross Plant Science, Southern Cross University, Lismore 2480, Australia
*
Author to whom correspondence should be addressed.
These authors contributed equally to the manuscript.
Mar. Drugs 2019, 17(3), 155; https://doi.org/10.3390/md17030155
Received: 29 January 2019 / Revised: 22 February 2019 / Accepted: 2 March 2019 / Published: 6 March 2019
(This article belongs to the Special Issue Marine Anti-inflammatory Agents)
  |  
PDF [1172 KB, uploaded 6 March 2019]
  |     |  

Abstract

Marine organisms are a rich source of biologically active lipids with anti-inflammatory activities. These lipids may be enriched in visceral organs that are waste products from common seafood. Gas chromatography-mass spectrometry and fatty acid methyl ester (FAME) analyses were performed to compare the fatty acid compositions of lipid extracts from some common seafood organisms, including octopus (Octopus tetricus), squid (Sepioteuthis australis), Australian sardine (Sardinops sagax), salmon (Salmo salar) and school prawns (Penaeus plebejus). The lipid extracts were tested for anti-inflammatory activity by assessing their inhibition of nitric oxide (NO) and tumor necrosis factor alpha (TNFα) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 mouse cells. The lipid extract from both the flesh and waste tissue all contained high amounts of polyunsaturated fatty acids (PUFAs) and significantly inhibited NO and TNFα production. Lipid extracts from the cephalopod mollusks S. australis and O. tetricus demonstrated the highest total PUFA content, the highest level of omega 3 (ω-3) PUFAs, and the highest anti-inflammatory activity. However, multivariate analysis indicates the complex mixture of saturated, monounsaturated, and polyunsaturated fatty acids may all influence the anti-inflammatory activity of marine lipid extracts. This study confirms that discarded parts of commonly consumed seafood species provide promising sources for the development of new potential anti-inflammatory nutraceuticals. View Full-Text
Keywords: seafood waste; polyunsaturated fatty acid; NO inhibition; fish oil; marine nutraceuticals seafood waste; polyunsaturated fatty acid; NO inhibition; fish oil; marine nutraceuticals
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Ahmad, T.B.; Rudd, D.; Kotiw, M.; Liu, L.; Benkendorff, K. Correlation between Fatty Acid Profile and Anti-Inflammatory Activity in Common Australian Seafood by-Products. Mar. Drugs 2019, 17, 155.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top