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Exploration of Indole Alkaloids from Marine Fungus Pseudallescheria boydii F44-1 Using an Amino Acid-Directed Strategy

1
School of Chemistry, Sun Yat-sen University, Guangzhou 510275, China
2
School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China
3
State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University, Guangzhou 510060, China
4
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2019, 17(2), 77; https://doi.org/10.3390/md17020077
Received: 20 December 2018 / Revised: 17 January 2019 / Accepted: 21 January 2019 / Published: 23 January 2019
(This article belongs to the Special Issue Strategies for Enhancing the Metabolome of Marine-Derived Fungi)
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Abstract

The composition of the culture medium has great influence on the metabolite production of the marine fungus Pseudallescheria boydii F44-1. By adding amino acids to GPY culture medium, two new bisindole alkaloids, pseudboindoles A and B (1 and 2), together with 11 known indole alkaloids were isolated from the culture broth. Their structures were elucidated by comprehensive analysis of the NMR, MS, IR, and UV spectra. The 3,3′-cyclohexylidenebis(1H-indole) (3) showed cytotoxic activity against various cancer cell lines. View Full-Text
Keywords: Pseudallescheria boydii; indole alkaloid; pseudboindole; cytotoxic activity Pseudallescheria boydii; indole alkaloid; pseudboindole; cytotoxic activity
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Yuan, M.-X.; Qiu, Y.; Ran, Y.-Q.; Feng, G.-K.; Deng, R.; Zhu, X.-F.; Lan, W.-J.; Li, H.-J. Exploration of Indole Alkaloids from Marine Fungus Pseudallescheria boydii F44-1 Using an Amino Acid-Directed Strategy. Mar. Drugs 2019, 17, 77.

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