Next Article in Journal
Exploration of Indole Alkaloids from Marine Fungus Pseudallescheria boydii F44-1 Using an Amino Acid-Directed Strategy
Previous Article in Journal
A Novel Mutant of rLj-RGD3 (rLj-112) Suppressed the Proliferation and Metastasis of B16 Cells through the EGFR Signaling Pathway
Previous Article in Special Issue
New Drugs from the Sea: Pro-Apoptotic Activity of Sponges and Algae Derived Compounds
Article Menu
Issue 2 (February) cover image

Export Article

Open AccessReview
Mar. Drugs 2019, 17(2), 76; https://doi.org/10.3390/md17020076

Regulated Cell Death Signaling Pathways and Marine Natural Products That Target Them

Marine Biomedical and Biotechnology Research, Harbor Branch Oceanographic Institute at Florida Atlantic University, 5600 US 1 North, Fort Pierce, FL 34946, USA
Received: 29 November 2018 / Revised: 15 January 2019 / Accepted: 16 January 2019 / Published: 23 January 2019
(This article belongs to the Special Issue Connection of Marine Natural Products and Cell Apoptosis)
Full-Text   |   PDF [1765 KB, uploaded 23 January 2019]   |  

Abstract

Our understanding of cell death used to consist in necrosis, an unregulated form, and apoptosis, regulated cell death. That understanding expanded to acknowledge that apoptosis happens through the intrinsic or extrinsic pathways. Actually, many other regulated cell death processes exist, including necroptosis, a regulated form of necrosis, and autophagy-dependent cell death. We also understand that apoptosis occurs beyond the intrinsic and extrinsic pathways with caspase independent forms of apoptosis existing. Our knowledge of the signaling continues to grow, and with that, so does our ability to target different parts of the pathways with small molecules. Marine natural products co-evolve with their targets, and these unique molecules have complex structures with exquisite biological activities and specificities. This article offers a review of our current understanding of the signaling pathways regulating cell death, and highlights marine natural products that can affect these signaling pathways. View Full-Text
Keywords: marine natural products; regulated cell death; apoptosis; anoikis; paraptosis; necroptosis; ferroptosis; parthanatos; mitotic catastrophe; autophagy marine natural products; regulated cell death; apoptosis; anoikis; paraptosis; necroptosis; ferroptosis; parthanatos; mitotic catastrophe; autophagy
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Guzmán, E.A. Regulated Cell Death Signaling Pathways and Marine Natural Products That Target Them. Mar. Drugs 2019, 17, 76.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top