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Mar. Drugs 2019, 17(2), 73; https://doi.org/10.3390/md17020073

Isolation and Potential Biological Applications of Haloaryl Secondary Metabolites from Macroalgae

1
Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal
2
Centro Interdisciplinar de Investigação Marinha e Ambiental (CIIMAR), Universidade do Porto, Terminal de Cruzeiros do Porto de Leixões, Avenida General Norton de Matos s/n 4450-208 Matosinhos, Portugal
*
Authors to whom correspondence should be addressed.
Received: 28 December 2018 / Revised: 16 January 2019 / Accepted: 18 January 2019 / Published: 22 January 2019
(This article belongs to the Special Issue Discovery and Application of Macroalgae-Derived Natural Products)
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Abstract

Macroalgae have been reported as an important source of halogenated aromatic secondary metabolites, being the majority of these derivatives isolated from red algae. Halophenols and haloindoles are the most common haloaryl secondary metabolites isolated from these marine organisms. Nevertheless, some halogenated aromatic sesquiterpenes and naphthalene derivatives have also been isolated. Most of these secondary metabolites showed interesting biological activities, such as antitumor, antimicrobial, antidiabetic, and antioxidant. This review describes in a systematic way the distribution and natural occurrence of halogenated aromatic secondary metabolites from extracts of red, brown, and green algae, as well as biological activities reported for these compounds. View Full-Text
Keywords: macroalgae; secondary metabolites; haloaryl compounds; biological activity macroalgae; secondary metabolites; haloaryl compounds; biological activity
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Jesus, A.; Correia-da-Silva, M.; Afonso, C.; Pinto, M.; Cidade, H. Isolation and Potential Biological Applications of Haloaryl Secondary Metabolites from Macroalgae. Mar. Drugs 2019, 17, 73.

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