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Mar. Drugs 2019, 17(2), 103; https://doi.org/10.3390/md17020103

Immunostimulatory Phosphatidylmonogalactosyldiacylglycerols (PGDG) from the Marine Diatom Thalassiosira weissflogii: Inspiration for a Novel Synthetic Toll-Like Receptor 4 Agonist

1
CNR-Institute of Biomolecular Chemistry, via Campi Flegrei, 34, 80078 Pozzuoli (Napoli), Italy
2
CNR-Institute of Protein Biochemistry, via Pietro Castellino, 111, 80131 Napoli, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Received: 16 January 2019 / Revised: 4 February 2019 / Accepted: 5 February 2019 / Published: 9 February 2019
(This article belongs to the Special Issue Bioactive Compounds Derived from Marine Microalgae)
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Abstract

An unprecedented phosphatidylmonogalactosyldiacylglycerol pool (PGDG, 1) rich in polyunsaturated fatty acids was isolated from the marine diatoms Thalassiosira weissflogii. Here we report for the first time the NMR characterization of this rare lipid from marine organisms along with a synthetic strategy for the preparation of a PGDG analog (2). PGDG 1 exhibited immunostimulatory activity in human dendritic cells (DCs) and the synthetic PGDG 2 was prepared to explore its mechanism of action. A Toll-like receptor-4 (TLR-4) agonistic activity was evidenced in human and murine DCs underlying the antigen-specific T-cell activation of this class of molecules. View Full-Text
Keywords: marine diatom; Thalassiosira weissflogii; phosphogalactolipids; Toll-like receptor 4; dendritic cells; immunostimulatory lipid; phosphoglycolipid synthesis marine diatom; Thalassiosira weissflogii; phosphogalactolipids; Toll-like receptor 4; dendritic cells; immunostimulatory lipid; phosphoglycolipid synthesis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Manzo, E.; Gallo, C.; Sartorius, R.; Nuzzo, G.; Sardo, A.; De Berardinis, P.; Fontana, A.; Cutignano, A. Immunostimulatory Phosphatidylmonogalactosyldiacylglycerols (PGDG) from the Marine Diatom Thalassiosira weissflogii: Inspiration for a Novel Synthetic Toll-Like Receptor 4 Agonist. Mar. Drugs 2019, 17, 103.

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