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Article

Protective Effects of Fucoxanthin against Alcoholic Liver Injury by Activation of Nrf2-Mediated Antioxidant Defense and Inhibition of TLR4-Mediated Inflammation

1
Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, China
2
Zhejiang Hailisheng Group Co., Ltd., Zhoushan 316021, China
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2019, 17(10), 552; https://doi.org/10.3390/md17100552
Received: 11 September 2019 / Revised: 22 September 2019 / Accepted: 27 September 2019 / Published: 27 September 2019
(This article belongs to the Special Issue Marine Carotenoids)
Fucoxanthin (Fx) is a natural extract from marine seaweed that has strong antioxidant activity and a variety of other bioactive effects. This study elucidated the protective mechanism of Fx on alcoholic liver injury. Administration of Fx was associated with lower pathological effects in liver tissue and lower serum marker concentrations for liver damage induced by alcohol. Fx also alleviated oxidative stress, and lowered the level of oxides and inflammation in liver tissue. Results indicate that Fx attenuated alcohol-induced oxidative lesions and inflammatory responses by activating the nuclear factor erythrocyte-2-related factor 2 (Nrf2)-mediated signaling pathway and down-regulating the expression of the toll-like receptor 4 (TLR4)-mediated nuclear factor-kappa B (NF-κB) signaling pathway, respectively. Our findings suggest that Fx can be developed as a potential nutraceutical for preventing alcohol-induced liver injury in the future. View Full-Text
Keywords: alcoholic liver injury; fucoxanthin; oxidative stress; Nrf2; TLR4 alcoholic liver injury; fucoxanthin; oxidative stress; Nrf2; TLR4
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MDPI and ACS Style

Zheng, J.; Tian, X.; Zhang, W.; Zheng, P.; Huang, F.; Ding, G.; Yang, Z. Protective Effects of Fucoxanthin against Alcoholic Liver Injury by Activation of Nrf2-Mediated Antioxidant Defense and Inhibition of TLR4-Mediated Inflammation. Mar. Drugs 2019, 17, 552. https://doi.org/10.3390/md17100552

AMA Style

Zheng J, Tian X, Zhang W, Zheng P, Huang F, Ding G, Yang Z. Protective Effects of Fucoxanthin against Alcoholic Liver Injury by Activation of Nrf2-Mediated Antioxidant Defense and Inhibition of TLR4-Mediated Inflammation. Marine Drugs. 2019; 17(10):552. https://doi.org/10.3390/md17100552

Chicago/Turabian Style

Zheng, Jiawen, Xiaoxiao Tian, Wen Zhang, Pingan Zheng, Fangfang Huang, Guofang Ding, and Zuisu Yang. 2019. "Protective Effects of Fucoxanthin against Alcoholic Liver Injury by Activation of Nrf2-Mediated Antioxidant Defense and Inhibition of TLR4-Mediated Inflammation" Marine Drugs 17, no. 10: 552. https://doi.org/10.3390/md17100552

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