Next Article in Journal
Biphasic Scaffolds from Marine Collagens for Regeneration of Osteochondral Defects
Next Article in Special Issue
Antartin, a Cytotoxic Zizaane-Type Sesquiterpenoid from a Streptomyces sp. Isolated from an Antarctic Marine Sediment
Previous Article in Journal
Synthesis and Biological Evaluation of a New Structural Simplified Analogue of cADPR, a Calcium-Mobilizing Secondary Messenger Firstly Isolated from Sea Urchin Eggs
Previous Article in Special Issue
Fluostatins M–Q Featuring a 6-5-6-6 Ring Skeleton and High Oxidized A-Rings from Marine Streptomyces sp. PKU-MA00045
Article Menu
Issue 3 (March) cover image

Export Article

Open AccessCommunication

New Naphthoquinone Terpenoids from Marine Actinobacterium, Streptomyces sp. CNQ-509

Natural Constituents Research Center, Korea Institute of Science and Technology (KIST), Gangneung, Gangwon-do 25451, Korea
Author to whom correspondence should be addressed.
Mar. Drugs 2018, 16(3), 90;
Received: 30 January 2018 / Revised: 8 March 2018 / Accepted: 9 March 2018 / Published: 12 March 2018
(This article belongs to the Special Issue Natural Products from Marine Actinomycetes)
PDF [1112 KB, uploaded 12 March 2018]


A member of the marine streptomycete clade MAR4, Streptomyces sp. CNQ-509, has genetic potential for the biosynthesis of hybrid isoprenoids and produces several meroterpenoids such as naphterpin, nitropyrrolin and marinophenazine. Our research on the strain CNQ-509 led to the isolation of two new naphterpin derivatives (1 and 2) comprised of naphthoquinone and geranyl moieties along with the known terpenoid, debromomarinone. The two-dimensional structure of these compounds was determined through spectral data analysis using data from NMR, MS and UV spectroscopy. Furthermore, the full structures of 1 and 2 including absolute configurations were unequivocally established by a combination of NMR experiments and chemical modifications. View Full-Text
Keywords: marine Actinobacteria; natural product; hybrid terpenoid; meroterpenoid marine Actinobacteria; natural product; hybrid terpenoid; meroterpenoid

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

Park, J.-S.; Kwon, H.C. New Naphthoquinone Terpenoids from Marine Actinobacterium, Streptomyces sp. CNQ-509. Mar. Drugs 2018, 16, 90.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top